Pankreas und Mikrobiom – Erkenntnisse für die Praxis

• Literatur

• 1 Frost F, Kacprowski T, Rühlemann M. et al Impaired Exocrine Pancreatic Function Associates With Changes in Intestinal Microbiota Composition and Diversity. In: Gastroenterology 2019; 156 (04) 1010-1015
• 2 Kurashima Y, Kigoshi T, Murasaki S. et al Pancreatic Glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation. In: Nature Communications 2021; 12: 1067
• 3 Ahuja M, Schwartz DM, Tandon M. et al Orai1-mediated antimicrobial secretion from pancreatic acini shapes the gut microbiome and regulates gut innate immunity. In: Cell Metabolism 2017; 25 (03) 635-646
• 4 Frost F, Kacprowski T, Rühlemann M. et al Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function. In: Gut 2021; 70: 522-530
• 5 Sendler M, Wilden A, Glaubitz J. et al Immunosuppression during severe acute pancreatitis is associated with a dramatic shift in intestinal microbiota composition and infected necrosis. [Abstract]. In: Pancreatology 2020; 20: S24
• 6 Frost F, Weiss FU, Sendler M. et al The Gut Microbiome in Patients With Chronic Pancreatitis Is Characterized by Significant Dysbiosis and Overgrowth by Opportunistic Pathogens. In: Clin Transl Gastroenterol 2020; 11 (09) e00232
• 7 Besselink MG, van Santvoort HC, Buskens E. et al Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. In: Lancet 2008; 371: 651-659