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DOI: 10.1055/a-1422-1763
A case of pancreatic schwannoma with a focus on contrast-enhanced endoscopic ultrasonography
A schwannoma is a benign peripheral nerve sheath tumor originating from Schwann cells [1]. Although schwannomas appear as well-demarcated hypoechoic masses on endoscopic ultrasonography (EUS) [2], there are few reports on pancreatic schwannoma diagnosed by EUS. A pancreatic schwannoma is difficult to diagnose preoperatively because of the lack of established imaging characteristics. We present a case of pancreatic schwannoma that was diagnosed by contrast-enhanced EUS and endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA).
A 54-year-old man was admitted to our hospital with a 12-mm tumor in the pancreatic body. The tumor was revealed on ultrasonography during a medical checkup without any symptoms. Contrast-enhanced computed tomography revealed a 10-mm hypovascular tumor in the pancreatic body ([Fig. 1]). Magnetic resonance imaging of the tumor revealed hypointensity on T1-weighted images, hyperintensity on T2-weighted images, and hyperintensity on diffusion-weighted images ([Fig. 2]). No abnormalities were observed on magnetic resonance cholangiopancreatography. EUS showed a 12-mm, clear-boundary, solid, round, and hypoechoic tumor in the pancreatic body. Contrast-enhanced EUS showed a hypovascular tumor compared with the surrounding pancreatic parenchyma ([Fig. 3]), and contrast-enhanced EUS findings were observed continuously over 2 minutes ([Video 1]). We performed EUS-FNA with a 22-gauge needle (Sono Tip Pro Control; Medi-Globe GmbH, Rosenheim, Germany) to make a pathological diagnosis. Histopathological examination revealed a proliferation of spindle cells. These tumor cells were positive for S-100 protein and negative for c-kit and desmin in immunohistochemical staining ([Fig. 4]). Based on these findings, the lesion was diagnosed as a schwannoma. The patient was carefully monitored without surgical resection.






Video 1 Hypovascular tumor compared with surrounding pancreatic parenchyma on contrast-enhanced endoscopic ultrasonography, observed continuously over 2 minutes. Cystic components were undetected. Endoscopic ultrasound-guided fine-needle aspiration was performed using a 22-gauge needle.
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Contrast-enhanced EUS images of this tumor had a slightly delayed enhancement; therefore, a solid pseudopapillary neoplasm and pancreatic neuroendocrine neoplasm were considered as differential diagnoses [3]. In conclusion, small and solid schwannomas may resemble solid pseudopapillary neoplasms and pancreatic neuroendocrine neoplasms. Therefore, contrast-enhanced EUS and EUS-FNA may be useful in avoiding surgical resection.
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Competing interests
The authors declare that they have no conflict of interest.
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References
- 1 Verocay J. Zur Kenntnis der Neurofibrome. Beitr Pathol Anat 1910; 48: 1-69
- 2 Ma Y, Shen B, Jia Y. et al. Pancreatic schwannoma: a case report and an updated 40-year review of the literature yielding 68 cases. BMC Cancer 2017; 17: 853
- 3 Ishikawa T, Itoh A, Kawashima H. et al. A case of solid-pseudopapillary neoplasm, focusing on contrast-enhanced endoscopic ultrasonography. J Med Ultrason 2011; 38: 209-216
Corresponding author
Publikationsverlauf
Artikel online veröffentlicht:
28. April 2021
© 2021. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
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References
- 1 Verocay J. Zur Kenntnis der Neurofibrome. Beitr Pathol Anat 1910; 48: 1-69
- 2 Ma Y, Shen B, Jia Y. et al. Pancreatic schwannoma: a case report and an updated 40-year review of the literature yielding 68 cases. BMC Cancer 2017; 17: 853
- 3 Ishikawa T, Itoh A, Kawashima H. et al. A case of solid-pseudopapillary neoplasm, focusing on contrast-enhanced endoscopic ultrasonography. J Med Ultrason 2011; 38: 209-216







