Manganese-Catalyzed C(sp2)–H Addition to Polar Unsaturated Bonds

Ting Liu; Congyang Wang

doi:10.1055/a-1468-6136

Synlett, Inhaltsverzeichnis

Synlett 2021; 32(13): 1323-1329
DOI: 10.1055/a-1468-6136

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Perspectives on Organoheteroatom and Organometallic Chemistry

Manganese-Catalyzed C(sp²)–H Addition to Polar Unsaturated Bonds

Ting Liu

^aBeijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. of China

^bUniversity of Chinese Academy of Sciences, Beijing 100049, P. R. of China

,

Congyang Wang ∗

^aBeijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. of China

^bUniversity of Chinese Academy of Sciences, Beijing 100049, P. R. of China

^cPhysical Science Laboratory, Huairou National Comprehensive Science Center, Beijing 101400, P. R. of China

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Abstract

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Abstract

Transition-metal-catalyzed nucleophilic C–H addition of hydrocarbons to polar unsaturated bonds could intrinsically avoid prefunctionalization of substrates and formation of waste byproducts, thus featuring high step- and atom-economy. As the third most abundant transition metal, manganese-catalyzed C–H addition to polar unsaturated bonds remains challenging, partially due to the difficulty in building a closed catalytic cycle of manganese. In the past few years, we have developed manganese catalysis to enable the sp²-hydrid C–H addition to polar unsaturated bonds (e.g., imines, aldehydes, nitriles), which will be discussed in this personal account.

1 Introduction

2 Mn-Catalyzed N-Directed C(sp²)–H Addition to Polar Unsaturated Bonds

3 Mn-Catalyzed O-Directed C(sp²)–H Addition to Polar Unsaturated Bonds

4 Conclusion

Key words

manganese - catalysis - C–H activation - polar unsaturated bonds - organic synthesis

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Referenzen

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