Generation of Aryllithium Reagents from N-Arylpyrroles Using Lithium

Abstract

Treatment of 1-aryl-2,5-diphenylpyrroles with lithium powder in tetrahydrofuran at 0 °C results in the generation of the corresponding aryllithium reagents through reductive C–N bond cleavage.

Key words

organolithium reagents - C–N bond cleavage - lithium - pyrroles - metalation - reduction - deamination

Publication History

Received: 10 March 2021

Accepted after revision: 14 April 2021

Accepted Manuscript online:
14 April 2021

Article published online:
19 May 2021

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