Generation of Aryllithium Reagents from N-Arylpyrroles Using Lithium

Tomoya Ozaki; Atsushi Kaga; Hayate Saito; Hideki Yorimitsu

doi:10.1055/a-1482-2567

Synthesis, Table of Contents

Synthesis 2021; 53(17): 3019-3028
DOI: 10.1055/a-1482-2567

special topic

Bond Activation – in Honor of Prof. Shinji Murai

Generation of Aryllithium Reagents from N-Arylpyrroles Using Lithium

Tomoya Ozaki

,

Atsushi Kaga

,

Hayate Saito

,

Hideki Yorimitsu ∗

Abstract

All articles of this category

Abstract

Treatment of 1-aryl-2,5-diphenylpyrroles with lithium powder in tetrahydrofuran at 0 °C results in the generation of the corresponding aryllithium reagents through reductive C–N bond cleavage.

Key words

organolithium reagents - C–N bond cleavage - lithium - pyrroles - metalation - reduction - deamination

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References

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