Tetrahydroxydiboron-Initiated Atom-Transfer Radical Cyclization

Abstract

In this work, the first diboron reagent initiated atom-transfer radical cyclization was reported, in which the boryl radicals were generated by the homolytic cleavage of a B–B single bond weakened by the coordination of Lewis base. To clarify the role of carbonate and DMF in the cleavage of B–B bond, we calculated the free energy diagram of two pathways by density functional theory (DFT) investigations. The DFT calculation showed that the presence of carbonate facilitates the B–B bond cleavage to form boron radicals, which can be further stabilized by DMF. Subsequent atom-transfer cyclization initiated by stabilized dihydroxyboron radical is also energetically favored.

Key words

tetrahydroxydiboron - homolytic cleavage - atom-transfer radical cyclization - radical initiator - density functional theory

Publication History

Received: 01 March 2021

Accepted after revision: 19 April 2021

Accepted Manuscript online:
19 April 2021

Article published online:
26 May 2021

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