Prevalence of Atherosclerotic Cardiovascular Disease, Heart Failure, and Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus: A Primary Care Research Network-based Study

Geert Goderis; Bert Vaes; Pavlos Mamouris; Eline van Craeyveld; Chantal Mathieu

doi:10.1055/a-1508-3912

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2022; 130(07): 447-453
DOI: 10.1055/a-1508-3912

Article

Prevalence of Atherosclerotic Cardiovascular Disease, Heart Failure, and Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus: A Primary Care Research Network-based Study

Geert Goderis

¹Academic Center for General Practice, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium

,

Bert Vaes

¹Academic Center for General Practice, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium

,

Pavlos Mamouris

¹Academic Center for General Practice, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium

,

Eline van Craeyveld

²Medical Department, Novo Nordisk Pharma Belux, Brussels, Belgium

,

Chantal Mathieu

³Clinical and Experimental Endocrinology, UZ Gasthuisberg, KU Leuven, Leuven, Belgium

› Author Affiliations

Abstract

Aims This study aims to assess the prevalence of atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), chronic kidney disease (CKD), and their combined presence in type 2 diabetes (T2D) patients in primary care for whom the 2019 ADA/EASD consensus update “Management of Hyperglycemia in Type 2 Diabetes” recommends GLP-1 receptor agonists (GLP-1RA) or sodium-glucose cotransporter-2 inhibitors (SGLT-I) as first-line medications after metformin.

Methods Data were obtained in 2015 from Intego, a morbidity registration network of 111 general practitioners (GPs) working in 48 practices and including 123 261 registered patients.

Results Of 123 261 patients, 9616 had T2D. Of these patients, 4200 (43.7%) presented with ASCVD and/or CKD and/or HF. Specifically, 3348 (34.8%) patients had ASCVD, 388 (4.0%) had heart failure, and 1402 (14.6%) had CKD. Compared to patients without any of these comorbidities, patients with at least 1 of these conditions were older (69.7 ±12.6 vs. 63.1±12.5 years), had higher LDL-C values (104.2±35.8 mg/dl vs. 97.2±37.7) and less frequently achieved the systolic blood pressure target of 140 mm Hg (53 vs. 61%) (all p<0.001). Comorbid patients also had significantly more other comorbidities, such as dementia or cancer; received more recommended medications, such as statins; and received less metformin. Most patients with HF (325; 3.4%) had ASCVD (114; 1.2%), CKD (76; 0.8%), or both (135; 1.4%). In total, 478 patients with CKD (5.0%) also had ASCVD.

Conclusions At the primary care level, 44% of T2D patients suffer from ASCVD, CKD, and/or HF, and thus qualify for GLP-1RA or SGLT2-I therapy.

Key words

ASCVD - heart failure - CKD - type 2 diabetes mellitus

Full Text

References

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Supplementary Material

Supplementary Material