Artischocke – Gemüsepflanze mit potenter Heilkraft

Summary

Trotz jahrzehntelanger, intensiver Forschung ist die Wirksamkeit der Artischocke noch immer nicht in klinischen Studien belegt. – Dennoch scheint eine Linderung von Verdauungsbeschwerden plausibel

Keywords

Heilpflanze - Artischocke - Magen-Darm-Beschwerden - Bitterstoffe - EMA

• Literatur

• 1 Ben Salem M, Ben Abdallah Kolsi R, Dhouibi R. et al Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats. BMC Complement Altern Med 2017; 17: 328
• 2 Ben Salem M, Affes H, Athmouni K. et al Chemicals compositions, antioxidant and anti-inflammatory activity of Cynara scolymus leaves extracts, and analysis of major bioactive polyphenols by HPLC. Evid Based Complement Alternat Med 2017; 2017: 4951937
• 3 Ben Salem M, Affes H, Dhouibi R. et al Effect of artichoke (cynara scolymus) on cardiac markers, lipid profile and antioxidants levels in tissue of HFD-induced obesity. Arch Physiol Biochem 2019; 1-11
• 4 Ben Salem M, Ksouda K, Dhouibi R. et al LC-MS/MS analysis and hepatoprotective activity of artichoke (Cynara scolymus L.) leaves extract against high fat diet-induced obesity in rats. Biomed Res Int 2019; 2019: 4851279
• 5 Ben Salem M, Affes H, Dhouibi R. et al Preventive effect of artichoke (Cynara scolymus L.) in kidney dysfunction against high fat-diet induced obesity in rats. Arch Physiol Biochem 2019; 1-7
• 6 Blaschek W, Hilgenfeldt U, Holzgrabe U, Reichling J, Ruth P, Schulz V. Hagers Enzyklopädie der Arzneistoffe und Drogen. Stuttgart: Wissenschaftliche Verlagsgesellschaft; 2016
• 7 Elsayed Elgarawany G, Abdou AG, Maher Taie D. et al Hepatoprotective effect of artichoke leaf extracts in comparison with silymarin on acetaminophen-induced hepatotoxicity in mice. J Immunoassay Immunochem 2020; 41: 84-96
• 8 Elsebai MF, Abass K, Hakkola J. et al The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials. Food Funct 2016; 7: 3006-3016
• 9 Fantini N, Colombo G, Giori A. et al Evidence of glycemia-lowering effect by a Cynara scolymus L. extract in normal and obese rats. Phytother Res 2011; 25: 463-466
• 10 Feltrin C, Farias IV, Sandjo Lp. et al Effects of standardized medicinal plant extracts on drug metabolism mediated by CYP3A4 and CYP2D6 enzymes. Chem Res Toxicol 2020; 33: 2408-2419
• 11 Gotardo AT, Mattos MIDS, Hueza IM. et al The effect of Cynara scolymus (artichoke) on maternal reproductive outcomes and fetal development in rats. Regul Toxicol Pharmacol 2019; 102: 74-78
• 12 Hassabou NF, Farag AF. Anticancer effects induced by artichoke extract in oral squamous carcinoma cell lines. J Egypt Natl Canc Inst 2020; 32: 17
• 13 Hayata M, Watanabe N, Kamio N. et al Cynaropicrin from Cynara scolymus L. suppresses Porphyromonas gingivalis LPS-induced production of inflammatory cytokines in human gingival fibroblasts and RANKL-induced osteoclast differentiation in RAW264. 7 cells. J Nat Med 2019; 73: 114-123
• 14 Hemati N, Venkatakrishnan K, Yarmohammadi S. et al The effects of supplementation with Cynara scolymus L. on anthropometric indices: A systematic review and dose-response meta-analysis of clinical trials. Complement Ther Med 2021; 56: 102612
• 15 Ishida K, Kojima R, Tsuboi M. et al Effects of artichoke leaf extract on acute gastric mucosal injury in rats. Biol Pharm Bull 2010; 33: 223-229
• 16 Jalili C, Moradi S, Babaei A. et al Effects of Cynara scolymus L. on glycemic indices: A systematic review and meta-analysis of randomized clinical trials. Complement Ther Med 2020; 52: 102496
• 17 Khattab HA, Wazzan MA, Al-Ahdab MA. Nephroprotective potential of artichoke leaves extract against gentamicin in rats: Antioxidant mechanisms. Pak J Pharm Sci 2016; 29 (05) 1775-1782
• 18 Mileo AM, Di Venere D, Linsalata V. et al Artichoke polyphenols induce apoptosis and decrease the invasive potential of the human breast cancer cell line MDA-MB231. J Cell Physiol 2012; 227: 3301-3309
• 19 Mohammed ET, Radi AM, Aleya L. et al Cynara scolymus leaves extract alleviates nandrolone decanoate-induced alterations in testicular function and sperm quality in albino rats. Environ Sci Pollut Res Int 2020; 27: 5009-5017
• 20 Moradi M, Sohrabi G, Golbidi M. et al Effects of artichoke on blood pressure: A systematic review and meta-analysis. Complement Ther Med 2021; 57: 102668
• 21 Nassar MI, Mohamed TK, Elshamy AI. et al Chemical constituents and anti-ulcerogenic potential of the scales of Cynara scolymus (artichoke) heads. J Sci Food Agric 2013; 93: 2494-2501
• 22 European Medicines Agency.European Union herbal monograph on Cynara cardunculus L. (syn. Cynara scolymus L.), (27.03.2018) folium Im Internet. https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-cynara-cardunculus-l-syn-cynara-scolymus-l-folium_en.pdf> Stand: 23.06.2021
• 23 European Medicines Agency. Cynarae folium. European Medicines Agency. Assessment report on Cynara cardunculus L. (syn. Cynara scolymus L.), folium (13.03.2019). Im Internet. https://www.ema.europa.eu/en/medicines/herbal/cynarae-folium#overview-section Stand: 23.06.2021
• 24 Pereira C, Barros L, José Alves M. et al Artichoke and milk thistle pills and syrups as sources of phenolic compounds with antimicrobial activity. Food Funct 2016; 7: 3083-3090
• 25 Salekzamani S, Ebrahimi-Mameghani M, Rezazadeh K. The antioxidant activity of artichoke (Cynara scolymus): A systematic review and meta-analysis of animal studies. Phytother Res 2019; 33: 55-71
• 26 Santos HO, Bueno AA, Mota JF. The effect of artichoke on lipid profile: A review of possible mechanisms of action. Pharmacol Res 2018; 137: 170-178
• 27 Turkiewicz IP, Wojdyło A, Tkacz K. et al Antidiabetic, anticholinesterase and antioxidant activity vs. terpenoids and phenolic compounds in selected new cultivars and hybrids of artichoke Cynara scolymus L. molecules 2019; 24: 1222