Idiopathic Frozen Shoulder in Individuals with Diabetes: Association
                    with Metabolic Control, Obesity, Antidiabetic Treatment and Demographic
                    Characteristics in Adults with Type 1 or 2 Diabetes from the DPV
                    Registry

Alexander J. Eckert; Maike Plaumann; Sigrid Pehlke; Christof Beck; Steffen Mühldorfer; Uwe Weickert; Markus Laimer; Martin Pfeifer; Lars Stechemesser; ReinhardW. Holl

doi:10.1055/a-1543-8559

Experimental and Clinical Endocrinology & Diabetes, Inhaltsverzeichnis

Exp Clin Endocrinol Diabetes 2022; 130(07): 468-474
DOI: 10.1055/a-1543-8559

Article

Idiopathic Frozen Shoulder in Individuals with Diabetes: Association with Metabolic Control, Obesity, Antidiabetic Treatment and Demographic Characteristics in Adults with Type 1 or 2 Diabetes from the DPV Registry

Alexander J. Eckert

¹Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany

²German Centre for Diabetes Research (DZD), Munich-Neuherberg, Germany

,

Maike Plaumann

³Diabetologische Schwerpunktpraxis Hannover, Hannover, Germany

,

Sigrid Pehlke

⁴PDG Praxisgemeinschaft, Idar-Oberstein, Germany

,

Christof Beck

⁵Klinik für Innere Medizin 4, Klinikum Nürnberg Süd, Nürnberg, Germany

,

Steffen Mühldorfer

⁶Department of Gastroenterology, Klinikum Bayreuth, Bayreuth, Germany

,

Uwe Weickert

⁷Department of Medicine II, SLK Kliniken Heilbronn, University of Heidelberg, Germany

,

Markus Laimer

⁸Universitätsklinik für Diabetologie, Endokrinologie, Ernährungsmedizin und Metabolismus, Universität Bern, Inselspital, Bern, Switzerland

,

Martin Pfeifer

⁹Division of Diabetology, Klinik Tettnang, Germany

,

Lars Stechemesser

¹⁰Department of Internal Medicine I, Paracelsus Medical University, Salzburg, Austria

,

ReinhardW. Holl

¹Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany

²German Centre for Diabetes Research (DZD), Munich-Neuherberg, Germany

› Institutsangaben

Abstract

Aims To examine the association of frozen shoulder (FS) with demographic and diabetes-related outcomes in individuals with type 1 (T1D) or type 2 (T2D) diabetes aged ≥30 years.

Materials and methods Multivariable logistic regression models, adjusted for demographics were used to calculate the proportion of FS in association with age, gender, diabetes duration, body mass index (BMI), haemoglobin A1C (HbA1c) and diabetes treatment.

Results The unadjusted percentage of FS was higher in T1D compared to T2D (0.22% vs. 0.06%). In T1D, adjusted regression models revealed higher prevalence of FS in women than men (0.26 [0.20–0.34] % vs. 0.15 [0.11–0.21] %, p=0.010). No significant relationship of age and BMI with FS was found in both diabetes types. Longer diabetes duration was associated with a higher proportion of FS in T1D (p<0.001) and T2D (p=0.004). In T1D, HbA1c >7% was related to a higher proportion of FS compared to HbA1c ≤7% (0.25 [0.19–0.32] vs. 0.12 [0.08–0.20] %, p=0.007), while an inverse relationship was found in T2D (HbA1c ≤7%: 0.08 [0.07–0.10] vs. HbA1c >7%: 0.05 [0.04–0.06] %, p=0.001).

Conclusions Different associations of FS with gender and HbA1c were observed for T1D and T2D; however, longer diabetes duration increases the risk for FS independent of diabetes type. Musculoskeletal diseases are still underreported in individuals with diabetes and awareness should be raised for FS as a specific diabetes complication.

Key words

adhesive capsulitis - periarthritis humeroscapularis - PHS - haemoglobin A1c, body-mass-index

Volltext

Referenzen

References
1 Inayat F, Ali NS, Shahid H, Younus F. Prevalence and determinants of frozen shoulder in patients with diabetes: a single center experience from Pakistan. Cureus 2017; 9: e1544
2 Wong PL, Tan HC. A review on frozen shoulder. Singapore Med J 2010; 51: 694-697
3 Kingston K, Curry EJ, Galvin JW. et al Shoulder adhesive capsulitis: epidemiology and predictors of surgery. J Shoulder Elbow Surg 2018; 27: 1437-1443
4 Li W, Lu N, Xu H. et al Case control study of risk factors for frozen shoulder in China. Int J Rheum Dis 2015; 18: 508-513
5 Zuckerman JD, Rokito A. Frozen shoulder: a consensus definition. J Shoulder Elbow Surg 2011; 20: 322-325
6 Harada Y, Iwahori Y, Kajita Y. et al Secondary frozen shoulder after traumatic anterior shoulder instability. JSES Int 2019; 4: 72-76
7 Fleck K. Schmerzmedizin: Wenn der diabetes die schulter angreift. Dtsch Arztebl. 2020 117. A-203 / B-183 / C-179
8 Holte KB, Juel NG, Brox JI. et al Hand, shoulder and back stiffness in long-term type 1 diabetes; cross-sectional association with skin collagen advanced glycation end-products. the dialong study. J Diabetes Complications 2017; 31: 1408-1414
9 Hwang KR, Murrell GA, Millar NL. et al Advanced glycation end products in idiopathic frozen shoulders. J Shoulder Elbow Surg 2016; 25: 981-988
10 Arkkila PE, Kantola IM, Viikari JS. et al Shoulder capsulitis in type I and II diabetic patients: Association with diabetic complications and related diseases. Ann Rheum Dis 1996; 55: 907-914
11 Sarkar RN, Banerjee S, Basu AK. et al Rheumatological manifestations of Diabetes Mellitus. J Indian Rheum Assoc 2003; 11: 25-29
12 Thomas SJ, McDougall C, Brown ID. et al Prevalence of symptoms and signs of shoulder problems in people with diabetes mellitus. J Shoulder Elbow Surg 2007; 16: 748-751
13 Zreik NH, Malik RA, Charalambous CP. Adhesive capsulitis of the shoulder and diabetes: A meta-analysis of prevalence. Muscles Ligaments Tendons J 2016; 6: 26-34
14 Juel NG, Brox JI, Brunborg C. et al Very high prevalence of frozen shoulder in patients with type 1 diabetes of >/=45 yearsʼ duration: The dialong shoulder study. Arch Phys Med Rehabil 2017; 98: 1551-1559
15 Yian EH, Contreras R, Sodl JF. Effects of glycemic control on prevalence of diabetic frozen shoulder. J Bone Joint Surg Am 2012; 94: 919-923
16 Chan JH, Ho BS, Alvi HM. et al The relationship between the incidence of adhesive capsulitis and hemoglobin A1c. J Shoulder Elbow Surg 2017; 26: 1834-1837
17 Hofer SE, Schwandt A, Holl RW. et al Standardized documentation in pediatric diabetology: Experience from Austria and Germany. J Diabetes Sci Technol 2016; 10: 1042-1049
18 Rosenbauer J, Dost A, Karges B. et al Improved metabolic control in children and adolescents with type 1 diabetes: A trend analysis using prospective multicenter data from Germany and Austria. Diabetes care 2012; 35: 80-86
19 Robinson CM, Seah KT, Chee YH. et al Frozen shoulder. J Bone Joint Surg Br 2012; 94: 1-9
20 Candela V, Giannicola G, Passaretti D. et al Adhesive capsulitis of the shoulder: Pain intensity and distribution. Musculoskelet Surg 2017; 101: 153-158
21 Wang JP, Huang TF, Ma HL. et al Manipulation under anaesthesia for frozen shoulder in patients with and without non-insulin dependent diabetes mellitus. Int Orthop 2010; 34: 1227-1232
22 Vastamaki H, Ristolainen L, Vastamaki M. Range of motion of diabetic frozen shoulder recovers to the contralateral level. J Int Med Res 2016; 44: 1191-1199
23 Jenkins EF, Thomas WJ, Corcoran JP. et al The outcome of manipulation under general anesthesia for the management of frozen shoulder in patients with diabetes mellitus. J Shoulder Elbow Surg 2012; 21: 1492-1498
24 Massoud SN, Pearse EO, Levy O. et al Operative management of the frozen shoulder in patients with diabetes. J Shoulder Elbow Surg 2002; 11: 609-613
25 Agrawal RP, Gothwal S, Tantia P. et al Prevalence of rheumatological manifestations in diabetic population from north-west India. J Assoc Physicians India 2014; 62: 788-792
26 Salek AK, Mamun MA, Haque MA. et al Serum triglyceride level in type 2 diabetes mellitus patients with or without frozen shoulder. Bangladesh Med Res Counc Bull 2010; 36: 64-67
27 Thomas SJ, McDougall C, Brown ID. et al Prevalence of symptoms and signs of shoulder problems in people with diabetes mellitus. J Shoulder Elbow Surg 2007; 16: 748-751
28 Laimer M, Jenni S, Stettler C. Insulin therapy in type 2 diabetes: a review of “when” over “how” up to “why”. Praxis (Bern 1994) 2015; 104: 181-185
29 Park HB, Gwark JY, Jung J. What serum lipid abnormalities are associated with adhesive capsulitis accompanied by diabetes?. Clin Orthop Relat Res 2018; 476: 2231-2237
30 Sung CM, Jung TS, Park HB. Are serum lipids involved in primary frozen shoulder? A case-control study. J Bone Joint Surg Am 2014; 96: 1828-1833
31 Alhashimi RAH. Analytical observational study of frozen shoulder among patients with diabetes mellitus. Joints 2018; 6: 141-144
32 Safran O, El-Haj M, Leibowitz G. et al Should patients with frozen shoulder be screened for diabetes mellitus?. Orthop J Sports Med 2017; 5: 2325967117716450
33 Leps C, Falz R, Sauer J. et al Epidemiological, economic valuation of musculoskeletal disorders for the ICD-10 class M75 Shoulder-lesions. Clinical Sports Medicine – Germany (KCS) 2012; 13: 1-6

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