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Synthesis 2022; 54(21): 4703-4710
DOI: 10.1055/a-1588-0072
DOI: 10.1055/a-1588-0072
special topic
Asymmetric C–H Functionalization
Ruthenium(II)/Chiral Carboxylic Acid Catalyzed Enantioselective C–H Functionalization of Sulfoximines
This work was supported in part by the Japan Society for the Promotion of Science (JSPS; KAKENHI grant number JP20H02730 and JP20H04794 in Hybrid Catalysis).
Abstract
Ruthenium(II)-catalyzed enantioselective C–H functionalization reactions of sulfoximines with sulfoxonium ylides are described. The combination of [RuCl2(p-cymene)]2 and a pseudo-C 2-symmetric binaphthyl monocarboxylic acid furnished the S-chiral products in 76:24 to 92:8 er.
Key words
ruthenium catalysis - C–H activation - asymmetric catalysis - chiral carboxylic acid - sulfoximineSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1588-0072.
- Supporting Information
Publication History
Received: 13 July 2021
Accepted after revision: 16 August 2021
Accepted Manuscript online:
16 August 2021
Article published online:
11 October 2021
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For selected recent reviews on C–H functionalization, see:
For selected reviews on Ru-catalyzed C–H functionalization, see:
For selected recent general reviews on enantioselective C–H functionalization, see:
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For other examples, see review:
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For other examples, see reviews:
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Sulfoximines are used as removable and reusable directing groups for C–H functionalization. For selected examples, see:
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