A 64-year-old woman without Helicobacter pylori infection underwent an esophagogastroduodenoscopy during a health examination. A 2-mm flat lesion (0-IIb) with faded color and harboring a regular arrangement of collecting venules was detected at the greater curvature of the gastric fundus. Narrow-band imaging (NBI) showed a distinct whitish lesion. Magnifying endoscopy with NBI revealed a regular microsurface and microvascular pattern without a demarcation line, and a noncancer diagnosis was made [1]. However, as the endoscopic features on white-light imaging still strongly suggested neoplastic lesion in the background of mucosa not infected by H. pylori, a biopsy was taken. Histologically, a gastric adenocarcinoma resembling fundic gland cells with submucosal invasion was seen ([Fig. 1]). A pathological diagnosis of gastric adenocarcinoma of the fundic-gland type [2]
[3] was further confirmed by immunohistochemical staining.
Fig. 1 A 2-mm flat lesion (0-IIb) with faded color and harboring a regular arrangement of collecting venules was detected at the greater curvature of the gastric fundus (yellow arrow): a distant view; b closer view. c Narrow-band imaging showed a distinct whitish lesion (yellow arrow). d A biopsy specimen showed a gastric adenocarcinoma of the fundic-gland type with submucosal invasion (red arrow).
Endoscopic submucosal dissection was performed. No residual tumor was detected in the resected specimen, indicating that the tumor had been completely removed by endoscopic biopsy ([Video 1]). Despite the lesion being the smallest ever reported, submucosal invasion was seen histologically. Adenocarcinoma rather than adenoma is appropriate naming for this kind of lesion. As gastric cancer without H. pylori infection is expected to become more prevalent, we believe that the endoscopic features of this case can help endoscopists to detect more gastric adenocarcinomas of the fundic-gland type at an earlier phase to ensure effective treatment.
Video 1 Minute gastric adenocarcinoma of the fundic-gland type with submucosal invasion.
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