Abstract
Over the past more than ten years, my laboratory has been engaged in the total synthesis, medicinal chemistry, and chemical biology studies on daptomycin. Our efforts are expected to advance new understanding of this effective cyclic lipodepsipeptide antibiotic. In this Account, this long journey is presented.
1 Introduction
2 Total Synthesis of Daptomycin
3 Medicinal Chemistry of Daptomycin
4 Molecular Comparison of Daptomycin and Kynomycin
5 New Insight into How Daptomycin Exerts Bactericidal Effect
6 Conclusion
Key words
daptomycin - total synthesis - ligation - medicinal chemistry - antibiotics
