Evaluation of a Zingiber officinale and Bixa orellana
					Supplement on the Gut Microbiota of Male Athletes: A Randomized
					Placebo-Controlled Trial

Diego Domínguez-Balmaseda; Carlo Bressa; Arantxa Fernández-Romero; Beatriz de Lucas; Margarita Pérez-Ruiz; Alejandro F. San Juan; Marc Roller; Nicolas Issaly; Mar Larrosa

doi:10.1055/a-1671-5766

Planta Medica, Table of Contents

Planta Med 2022; 88(13): 1245-1255
DOI: 10.1055/a-1671-5766

Natural Product Chemistry and Analytical Studies

Original Papers

Evaluation of a Zingiber officinale and Bixa orellana Supplement on the Gut Microbiota of Male Athletes: A Randomized Placebo-Controlled Trial

Diego Domínguez-Balmaseda

¹Masmicrobiota Group, Faculty of Health Sciences, Universidad Europea de Madrid, Villaviciosa de Odón, Madrid, Spain

,

Carlo Bressa

¹Masmicrobiota Group, Faculty of Health Sciences, Universidad Europea de Madrid, Villaviciosa de Odón, Madrid, Spain

²Biomedicine Department, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Madrid, Spain

,

Arantxa Fernández-Romero

¹Masmicrobiota Group, Faculty of Health Sciences, Universidad Europea de Madrid, Villaviciosa de Odón, Madrid, Spain

,

Beatriz de Lucas

¹Masmicrobiota Group, Faculty of Health Sciences, Universidad Europea de Madrid, Villaviciosa de Odón, Madrid, Spain

,

Margarita Pérez-Ruiz

³Research Group on Exercise, health and biomarkers applied, Faculty of Sport Sciences, Universidad Europea de Madrid, Villaviciosa de Odón, Madrid, Spain

,

Alejandro F. San Juan

⁴Department of Health and Human Performance, Sport Biomechanics Laboratory, Faculty of Physical Activity and Sport Sciences, INEF, Universidad Politécnica de Madrid, Madrid, Spain

,

Marc Roller

⁵Natural Origins, Lozanne, France

,

Nicolas Issaly

⁶Nicolas Issaly, Valencia, Spain

,

Mar Larrosa

¹Masmicrobiota Group, Faculty of Health Sciences, Universidad Europea de Madrid, Villaviciosa de Odón, Madrid, Spain

⁷Department of Nutrition and Food Science, School of Pharmacy, Complutense University of Madrid (UCM), Madrid, Spain

› Author Affiliations

Abstract

The gut microbiota has emerged as a factor that influences exercise performance and recovery. The present study aimed to test the effect of a polyherbal supplement containing ginger and annatto called “ReWin(d)” on the gut microbiota of recreational athletes in a pilot, randomized, triple-blind, placebo-controlled trial. Thirty-four participants who practice physical activity at least three times weekly were randomly allocated to two groups, a ReWin(d) group or a maltodextrin (placebo) group. We evaluated the gut microbiota, the production of short-chain fatty acids, and the serum levels of interleukin-6 and lipopolysaccharide at baseline and after 4 weeks. Results showed that ReWin(d) supplementation slightly increased gut microbiota diversity. Pairwise analysis revealed an increase in the relative abundance of Lachnospira (β-coefficient = 0.013; p = 0.001), Subdoligranulum (β-coefficient = 0.016; p = 0.016), Roseburia (β-coefficient = 0.019; p = 0.001), and Butyricicoccus (β-coefficient = 0.005; p = 0.035) genera in the ReWin(d) group, and a decrease in Lachnoclostridium (β-coefficient = − 0.008; p = 0.009) and the Christensenellaceae R7 group (β-coefficient = − 0.010; p < 0.001). Moreover, the Christensenellaceae R-7 group correlated positively with serum interleukin-6 (ρ = 0.4122; p = 0.032), whereas the Lachnospira genus correlated negatively with interleukin-6 (ρ = − 0.399; p = 0.032). ReWin(d) supplementation had no effect on short-chain fatty acid production or on interleukin-6 or lipopolysaccharide levels.

Key words

Zingiber officinale - Zingiberaceae - Bixa orellana - Bixaceae - gingerol - gut microbiota - alpha-diversity

Full Text

References

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