Cationic Iridium/Chiral Bidentate Phosphoramidite Catalyzed Asymmetric Hydroarylation

Abstract

In this personal account, we summarize our investigations on the asymmetric direct addition of C(sp²)–H bonds to unsaturated bonds, such as C=O and C=C, using cationic iridium/chiral O-linked bidentate phosphoramidite (Me-BIPAM) and S-linked bidentate phosphoramidite (S-Me-BIPAM) catalyst systems.

1 Introduction

2 Highly Enantioselective Intramolecular Hydroarylation of α-Keto Amides

3 Highly Enantioselective Intermolecular Hydroarylation of Bicyclo­alkenes

4 Conclusion

Key words

asymmetric synthesis - C–H functionalization - hydroaryl­ation - iridium catalysts - chiral bidentate phosphoramidites

Publication History

Received: 05 October 2021

Accepted after revision: 01 November 2021

Accepted Manuscript online:
01 November 2021

Article published online:
14 December 2021

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