Transition-Metal-Catalyzed Enantioselective Synthesis of Indoles from 2-Alkynylanilines

Zhi-Shi Ye; Jin-Chen Li; Gang Wang

doi:10.1055/a-1729-9572

Synthesis, Inhaltsverzeichnis

Synthesis 2022; 54(09): 2133-2147
DOI: 10.1055/a-1729-9572

short review

Transition-Metal-Catalyzed Enantioselective Synthesis of Indoles from 2-Alkynylanilines

Autor*innen

Zhi-Shi Ye ∗
Jin-Chen Li
Gang Wang

Abstract

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Abstract

Optically active indole derivatives are ubiquitous in natural products and are widely recognized as privileged components in pharmacologically relevant compounds. Therefore, developing catalytic asymmetric approaches for constructing indole derivatives is highly desirable. In this short review, we summarize methods for the transition-metal-catalyzed enantioselective synthesis of indoles from 2-alkynylanilines.

1 Introduction

2 Aminometalation-Triggered Asymmetric Cross-Coupling Reactions/Insertion

2.1 Asymmetric Cross-Coupling Reactions

2.2 Asymmetric Insertion of C=O, C=C and C≡N Bonds

3 Asymmetric Relay Catalysis

4 Conclusion

Key words

indoles - 2-alkynylanilines - aminometalation - cross-coupling - insertion - relay catalysis - axial chirality

Volltext

Referenzen

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