Total Synthesis of Cryptopleurine and Its Analogues

Abstract

Total synthesis of phenanthroquinolizidine alkaloid cryptopleurine was achieved in 8 steps from commercially available 2-pyridinecarboxaldehyde and the epoxide derived from methyleugenol. The key intermediate vinyl triflate enables the divergent synthesis of crypto­pleurine derivatives by late-stage installation of various substituents on the C-ring.

Key words

heterocycles - phenanthroquinolizidines - cryptopleurine - natural product synthesis - cyclization - anticancer agents

• References


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