Development of Heterocyclic Multicomponent Reactions through Guided Exploration: Direct, Reasonable and Unpredictable Processes

Ouldouz Ghashghaei; Pau Nadal Rodríguez; Rodolfo Lavilla

doi:10.1055/a-1750-3185

Synlett, Table of Contents

Synlett 2022; 33(09): 822-835
DOI: 10.1055/a-1750-3185

account

Development of Heterocyclic Multicomponent Reactions through Guided Exploration: Direct, Reasonable and Unpredictable Processes

Ouldouz Ghashghaei

,

Pau Nadal Rodríguez

,

Rodolfo Lavilla∗

Abstract

All articles of this category

This Account is dedicated to Prof. Mercedes Alvarez (University of Barcelona) on the occasion of her retirement, for her mentorship and support

Abstract

This Account summarizes the research of the group on the multicomponent reactions arena with fundamental heterocycles as substrates, using mechanistic considerations to hypothesize new processes and to rationalize results. Biomedical applications of the ensuing adducts were also envisaged, which brought about interesting discoveries.

1 Introduction and Context

2 The Beginnings: Unexplored Heterocyclic Substrates

3 Interrupted Processes

4 Multiple Multicomponent Reactions: Problem of Selectivity

5 Extended Multicomponent Reactions

6 Conclusions and Wishes

Key words

azines - azoles - heterocycles - multicomponent reactions - reaction discovery - reaction mechanism

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