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DOI: 10.1055/a-1772-4866
Simultaneous Multifrequency (SiMFy) Stimulus: A Novel and Reliable Stimulus for Frequency Tuning of Ocular Vestibular-Evoked Myogenic Potentials
Funding The study was not funded by any funding agency![](https://www.thieme-connect.de/media/10.1055-s-00046128/202204/lookinside/thumbnails/10-1055-a-1772-4866_21088-1.jpg)
Abstract
Background Frequency tuning of ocular vestibular evoked myogenic potential (oVEMP) refers to the frequency of tone burst that produces the largest amplitude oVEMP. There is an ever-growing pool of published studies that found the frequency tuning of oVEMP distinctly different in Ménière's disease than the age-matched controls and benign paroxysmal positional vertigo. However, recording oVEMP in response to many frequencies makes an already lengthy vestibular test battery even more cumbersome and time-consuming.
Purpose The aim of this study was to develop a novel time-saving stimulus that produces reliable results.
Research Design Prospective study.
Study Sample The study included 25 young, healthy adults.
Data Collection The tone-bursts of 2000, 1500, 1000, 750, 500, and 250 Hz were generated and sequenced in this order to prepare a stimulus for simultaneous multifrequency (SiMFy) oVEMP. The response parameters of SiMFy and conventional oVEMP methods were compared.
Results No significant difference in peak-to-peak amplitude and frequency tuning existed between conventional and SiMFy oVEMP (p > 0.05). SiMFy had better test–retest reliability and was less time-consuming than the conventional oVEMP.
Conclusions SiMFy is a time-saving and reliable stimulus for obtaining frequency tuning of oVEMP with no compromise on the outcomes. It can be immediately applied in most commercially available evoked potential systems with a facility for loading an external stimulus.
List of Abbreviations
SiMFy: Simultaneous multi-frequency
oVEMP: Ocular vestibular evoked myogenic potential
cVEMP: Cervical vestibular evoked myogenic potential
BPPV: Benign paroxysmal positional vertigo
SCD: Superior canal dehiscence
ABR: Auditory brainstem response
dBHL: Decibel hearing level
dB peSPL: Decibel peak sound pressure level
ICC: Intraclass correlation coefficient
Ethics Approval
The method used in the study was approved by the institutional review board.
Consent to Participate
Before testing, each participant was described regarding the experiment, and subsequently, written consent for participation was obtained.
Paper Presentation
This study is a part of the paper presented at the 50th Annual Convention of the Indian Speech and Hearing Association held at Mysore, India, January 5–7, 2018.
Disclaimer
Any mention of a product, service, or procedure in the Journal of the American Academy of Audiology does not constitute an endorsement of the product, service, or procedure by the American Academy of Audiology.
Publication History
Received: 08 September 2021
Accepted: 04 February 2022
Accepted Manuscript online:
15 February 2022
Article published online:
06 December 2022
© 2022. American Academy of Audiology. This article is published by Thieme.
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References
- 1 Sandhu JS, Low R, Rea PA, Saunders NC. Altered frequency dynamics of cervical and ocular vestibular evoked myogenic potentials in patients with Ménière's disease. Otol Neurotol 2012; 33 (03) 444-449
- 2 Taylor RL, Bradshaw AP, Halmagyi GM, Welgampola MS. Tuning characteristics of ocular and cervical vestibular evoked myogenic potentials in intact and dehiscent ears. Audiol Neurotol 2012; 17 (04) 207-218
- 3 Winters SM, Berg IT, Grolman W, Klis SF. Ocular vestibular evoked myogenic potentials: frequency tuning to air-conducted acoustic stimuli in healthy subjects and Ménière's disease. Audiol Neurotol 2012; 17 (01) 12-19
- 4 Piker EG, Jacobson GP, Burkard RF, McCaslin DL, Hood LJ. Effects of age on the tuning of the cVEMP and oVEMP. Ear Hear 2013; 34 (06) e65-e73
- 5 Singh NK, Barman A. Utility of the frequency tuning measure of oVEMP in differentiating Ménière's disease from BPPV. J Am Acad Audiol 2016a; 27 (09) 764-777
- 6 Singh NK, Firdose H. Characterizing the age and stimulus frequency interaction for ocular vestibular-evoked myogenic potentials. Ear Hear 2018; 39 (02) 251-259
- 7 Singh NK, Firdose H, Barman A. Effect of advancing age on inter-frequency amplitude ratio of ocular vestibular evoked myogenic potentials. Int J Audiol 2021; 60 (12) 995-999
- 8 Jerin C, Berman A, Krause E, Ertl-Wagner B, Gürkov R. Ocular vestibular evoked myogenic potential frequency tuning in certain Ménière's disease. Hear Res 2014; 310: 54-59
- 9 Singh NK, Barman A. Frequency–amplitude ratio of ocular vestibular-evoked myogenic potentials for detecting Ménière's disease: a preliminary investigation. Ear Hear 2016b; 37 (03) 365-373
- 10 Singh NK, Barman A. Inter-frequency amplitude ratio of oVEMP for differentiating Ménière's disease from BPPV: clinical validation using a double-blind approach. Int J Audiol 2019; 58 (01) 21-28
- 11 Winters SM, Campschroer T, Grolman W, Klis SF. Ocular vestibular evoked myogenic potentials in response to air-conducted sound in Ménière's disease. Otol Neurotol 2011; 32 (08) 1273-1280
- 12 Taylor RL, Zagami AS, Gibson WP. et al. Vestibular evoked myogenic potentials to sound and vibration: characteristics in vestibular migraine that enable separation from Ménière's disease. Cephalalgia 2012; 32 (03) 213-225
- 13 Oh SY, Dieterich M, Lee BN. et al. Endolymphatic hydrops in patients with vestibular migraine and concurrent Ménière's disease. Front Neurol 2021; 12: 594481
- 14 Wladislavosky-Waserman P, Facer GW, Mokri B, Kurland LT. Ménière's disease: a 30-year epidemiologic and clinical study in Rochester, Mn, 1951-1980. Laryngoscope 1984; 94 (08) 1098-1102
- 15 Havia M, Kentala E, Pyykkö I. Prevalence of Menière's disease in general population of Southern Finland. Otolaryngol Head Neck Surg 2005; 133 (05) 762-768
- 16 Tran ED, Swanson A, Sharon JD. et al. Ocular vestibular-evoked myogenic potential amplitudes elicited at 4 kHz optimize detection of superior semicircular canal dehiscence. Front Neurol 2020; 11: 879
- 17 Maheu M, Elblidi A, Saliba I. Investigating performance of cVEMP and oVEMP in the identification of superior canal dehiscence in relation to dehiscence location and size. Audiology Res 2021; 11 (03) 452-462
- 18 Singh NK, Kadisonga P, Ashitha P. Optimizing stimulus repetition rate for recording ocular vestibular evoked myogenic potential elicited by air-conduction tone bursts of 500 Hz. Audiology Res 2014; 4 (01) 88
- 19 Bogle JM, Zapala DA, Burkhardt B. et al. The effect of repetition rate on air-conducted ocular vestibular evoked myogenic potentials (oVEMPs). Am J Audiol 2015; 24 (03) 411-418
- 20 Singh NK, Kumar P, Jha RH. A novel stimulation paradigm for obtaining interfrequency amplitude ratio of ocular vestibular evoked myogenic potentials. Am J Audiol 2019; 28 (2S): 422-427
- 21 Ravikumar MH. Auditory brainstem response using chained stimuli of multi frequency tone bursts. Unpublished Masters dissertation, University of Mysore; 2016
- 22 Portnuff CDF, Kleindienst S, Bogle JM. Safe use of acoustic vestibular-evoked myogenic potential stimuli: protocol and patient-specific considerations. J Am Acad Audiol 2017; 28 (08) 708-717
- 23 Singh NK, Keloth NK, Sinha S. Is there a safe level for recording vestibular evoked myogenic potential? Evidence from cochlear and hearing function tests. Ear Hear 2019; 40 (03) 493-500
- 24 ANSI S. 13: maximum permissible ambient noise audiometric testing. New York: American National Standards Institute; 1991
- 25 Singh NK, Raul A, Malik G, Sao T. Intersession variations in frequency tuning of ocular vestibular evoked myogenic potentials in healthy individuals. Am J Audiol 2019; 28 (2S): 407-413
- 26 Shrout PE, Fleiss JL. Intraclass correlations: uses in assessing rater reliability. Psychol Bull 1979; 86 (02) 420-428
- 27 Versino M, Colnaghi S, Callieco R, Cosi V. Vestibular evoked myogenic potentials: test-retest reliability. Funct Neurol 2001; 16 (04) 299-309
- 28 Murnane OD, Akin FW, Kelly KJ, Byrd S. Effects of stimulus and recording parameters on the air conduction ocular vestibular evoked myogenic potential. J Am Acad Audiol 2011; 22 (07) 469-480
- 29 Chihara Y, Iwasaki S, Fujimoto C, Ushio M, Yamasoba T, Murofushi T. Frequency tuning properties of ocular vestibular evoked myogenic potentials. Neuroreport 2009; 20 (16) 1491-1495
- 30 Lewis A, Mustain W, Xu Y, Eby T, Zhou W. Frequency tuning in the tone burst-evoked myogenic potentials in extraocular muscles in normal human subjects. J Otolaryngol Head Neck Surg 2010; 39 (05) 491-497
- 31 Todd NP, Cody FW, Banks JR. A saccular origin of frequency tuning in myogenic vestibular evoked potentials?: implications for human responses to loud sounds. Hear Res 2000; 141 (1-2): 180-188
- 32 Todd NP, Rosengren SM, Colebatch JG. A utricular origin of frequency tuning to low-frequency vibration in the human vestibular system?. Neurosci Lett 2009; 451 (03) 175-180
- 33 Colletti V. Multifrequency tympanometry. Audiology 1977; 16 (04) 278-287
- 34 Shanks JE. Tympanometry. Ear Hear 1984; 5 (05) 268-280
- 35 Valvik BR, Johnsen M, Laukli E. Multifrequency tympanometry. Preliminary experiences with a commercially available middle-ear analyzer. Audiology 1994; 33 (05) 245-253