Durchführung und Befundung der 123I-mIBG-Szintigraphie bei Kindern und Jugendlichen mit Neuroblastom (Version 3) – DGN-Handlungsempfehlung (S1-Leitlinie), Stand: 2/2020 – AWMF-Registernummer: 031-040

Matthias Schmidt; Boris Decarolis; Christiane Franzius; Barbara Hero; Thomas Pfluger; Julian Manuel Michael Rogasch; Thorsten Simon

doi:10.1055/a-1778-3052

Nuklearmedizin - NuclearMedicine, Table of Contents

Nuklearmedizin 2022; 61(02): 96-110
DOI: 10.1055/a-1778-3052

Continuing Medical Education

Durchführung und Befundung der ¹²³I-mIBG-Szintigraphie bei Kindern und Jugendlichen mit Neuroblastom (Version 3) – DGN-Handlungsempfehlung (S1-Leitlinie), Stand: 2/2020 – AWMF-Registernummer: 031-040

Matthias Schmidt

¹Klinik und Poliklinik für Nuklearmedizin, Universitätsklinikum Köln, Köln (Cologne), Germany

,

Boris Decarolis

²Klinik und Poliklinik für Kinderheilkunde, Abteilung Kinderonkologie und –Hämatologie, Universitätsklinikum Köln, Köln (Cologne), Germany

,

Christiane Franzius

³Zentrum für moderne Diagnostik (ZeMoDi), MR- und MR/PET, Schwachhauser Heerstraße 63 A, 28211 Bremen, ZeMoDi, Bremen, Germany

,

Barbara Hero

²Klinik und Poliklinik für Kinderheilkunde, Abteilung Kinderonkologie und –Hämatologie, Universitätsklinikum Köln, Köln (Cologne), Germany

,

Thomas Pfluger

⁴Department of Nuclear Medicine, Ludwig-Maximilians-University, Munich, Germany

,

Julian Manuel Michael Rogasch

⁵Department of Nuclear Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany

,

Thorsten Simon

²Klinik und Poliklinik für Kinderheilkunde, Abteilung Kinderonkologie und –Hämatologie, Universitätsklinikum Köln, Köln (Cologne), Germany

› Author Affiliations

Abstract

Zusammenfasssung

Die aktualisierte 3. Fassung der ¹²³I-mIBG-Szintigrafie bei Kindern und Jugendlichen berücksichtigt folgende aktuelle Entwicklungen: Die Leitlinie fokussiert auf die diagnostische Anwendung von ¹²³I-mIBG beim Neuroblastom. ¹³¹I-mIBG kommt bei der Radionuklidtherapie zum Einsatz. An wenigen Stellen wird auf Besonderheiten des ¹³¹I-mIBG bei der Befundung von Posttherapie-Szintigrammen eingegangen. Es werden aktuelle Entwicklungen in der Patientenvorbereitung bei den Medikamenteninterferenzen und Empfehlungen zur Schilddrüsenblockade berücksichtigt. Neue Empfehlungen der zu applizierenden Aktivität werden genannt und die damit assoziierten Probleme diskutiert. Die Bildakquisition unter Berücksichtigung von SPECT bzw. SPECT/CT des Körperstammes inkl. des Kopfes wird berücksichtigt. Die Befundung unter Verwendung des SIOPEN-Scores wird neu aufgenommen. Auf PET bzw. PET/CT mit ¹⁸F-DOPA bzw. ⁶⁸Ga-DotaTATE wird verwiesen.

Schlüsselwörter

123I-mIBG-Szintigraphie - Neuroblastom - Kinder und Jugendliche - Diagnostik

Full Text

References

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