Erratum
Letrozole vs. Placebo Pretreatment in the Medical Management of First Trimester Missed Miscarriage: a Randomized Controlled Trial
Haitham A. Torky, Heba Marie, ElSayed
ElDesouky, Samy Gebreel, Osama Raslan, Asem A. Moussa, Ali M. Ahmad, Eman Zain, Mohamed N. Mohsen
Geburtsh Frauenheilk 2018; 78: 63–69
doi:10.1055/s-0043-122499
“Material and Methods”
Under the heading “Randomization and blinding” the sentence should read in full: Concealment was achieved using opaque envelopes, to blind the pysicians, while to blind the patients, the
placebo tablet was methylcellulose resembling letrozole in shape.
“Results”
In the 1st paragraph, the last sentence correctly reads: There were no significant differences in age and gestational age between the two groups ([Table
1]).
Under the heading “Comparison of gravidity”, the p-value has been corrected in the last sentence of the 1st paragraph. Correct is: p = 0.742.
Under the heading “Comparison of previous cesarean sections”, the p-value has been corrected in the penultimate sentence. Correct is: p = 0.117.
[Table 1] has been corrected. Correct is:
Table 1 Comparison of demographic data.
|
Demographic data
|
Group 1 (placebo)
|
Group 2 (letrozole)
|
p-value
|
|
Age
|
|
|
0.863
|
|
Mean ± SD
Range
|
26.62 ± 4.30
19 – 40
|
26.52 ± 3.87
19 – 35
|
|
|
Body mass index
|
|
|
0.0163
|
|
Mean ± SD
Range
|
25.81 ± 2.7
16.53 – 33.33
|
25.12 ± 3.3
19.37 – 37.46
|
|
|
Gestational age
|
|
|
0.065
|
|
Mean ± SD
Range
|
48.83 ± 8.00
35 – 62
|
50.19 ± 7.478
35 – 63
|
|
|
Gravidity
|
|
|
0.742
|
|
Gravida 1
|
46
|
54
|
|
|
Gravida 2
|
61
|
55
|
|
|
Gravida 3
|
22
|
22
|
|
|
Gravida 4
|
4
|
7
|
|
|
Gravida 5
|
86
|
81
|
|
|
Parity
|
|
|
0.891
|
|
Para 0
|
59
|
66
|
|
|
Para 1
|
57
|
52
|
|
|
Para 2
|
20
|
19
|
|
|
Para 3
|
3
|
4
|
|
|
Para 4
|
80
|
78
|
|
|
Previous cesarean section (CS)
|
|
|
0.117
|
|
No previous CS
|
92
|
116
|
|
|
1 previous CS
|
92
|
77
|
|
|
2 previous CS
|
21
|
19
|
|
|
3 previous CS
|
11
|
4
|
|
|
4 previous CS
|
3
|
3
|
|
[Table 2] has been corrected. Correct is:
Table 2 Comparison of failure rates between groups.
|
Failure rate
|
Group 1 (placebo)
|
Group 2 (letrozole)
|
Chi-square test
|
|
n
|
%
|
n
|
%
|
p-value
|
|
No (complete miscarriage)
|
85
|
39
|
171
|
78
|
< 0.001
|
|
Yes (incomplete miscarriage)
|
134
|
61
|
48
|
22
|
[Table 3] has been corrected. Correct is:
Table 3 Comparison of onset and duration of vaginal bleeding and onset of passing products of conception (clinical data).
|
Clinical findings
|
Group 1 (placebo)
|
Group 2 (letrozole)
|
p-value
|
|
Time to 1st vaginal bleeding after administration of misoprostol, days
|
|
|
< 0.001
|
|
Mean ± SD
Range
|
2.30 ± 0.64
1 – 4
|
1.33 ± 0.29
1 – 3
|
|
|
Time to induction of abortion after administration of misoprostol, days
|
3.09 ± 0.99
|
1.42 ± 0.50
|
< 0.001
|
|
Mean ± SD
Range
|
2 – 7
|
1 – 2
|
|
|
Time to 1st product of conception passed after administration of misoprostol, days
|
3.50 ± 1.55
|
2.09 ± 0.70
|
< 0.001
|
|
Mean ± SD
Range
|
2 – 9
|
1 – 7
|
|
[Table 4] has been corrected. Correct is:
Table 4 Comparison of side effects of medication.
|
Side effects
|
Group 1 (placebo)
|
Group 2 (letrozole)
|
Chi-square test
|
|
No
|
%
|
No
|
%
|
p-value
|
|
Nausea and vomiting
|
7
|
3
|
37
|
17
|
0.002
|
|
Fever
|
16
|
7
|
9
|
4
|
0.152
|
|
Severe pain
|
15
|
7
|
24
|
11
|
0.132
|
|
Severe bleeding needing evacuation
|
48
|
22
|
36
|
16
|
0.141
|
