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Synthesis 2022; 54(14): 3271-3281
DOI: 10.1055/a-1787-3958
DOI: 10.1055/a-1787-3958
paper
Rh(III)-Catalyzed Tandem [4+2] Annulation To Construct Functional Dihydroisoquinolinones
This work was supported by the National Natural Science Foundation of China (21572262). We are grateful for the research platform provided by Sichuan Normal University.
Abstract
A highly efficient Rh(III)-catalyzed tandem [4+2] annulation to construct functional dihydroisoquinolinone derivatives with an alkenyl side chain by insertion into an N–O bond as an internal oxidation process has been achieved. A wide range of 1,3-dienes as the coupling partners makes this simple methodology even more useful.
Key words
1,3-dienes - rhodium(III) catalysis - tandem [4+2] annulation - dihydroisoquinolinones - internal oxidantSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1787-3958.
- Supporting Information
Publication History
Received: 14 January 2022
Accepted after revision: 03 March 2022
Accepted Manuscript online:
03 March 2022
Article published online:
21 April 2022
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