Synthesis 2022; 54(22): 5026-5034
DOI: 10.1055/a-1846-5598
special topic
Aryne Chemistry in Synthesis

Poly(ethylene glycol) Dimethyl Ethers (PEGDME): Efficient and Recyclable Solvents for Aryne-Involved Reactions

Shweta Rai
a   Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India
c   Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
,
Polasani Samatha
a   Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India
,
Ramunaidu Addipilli
b   Centre for Mass Spectrometry, Department of Analytical & Structural Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India
c   Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
,
a   Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India
c   Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
,
Prabhakar Sripadi
b   Centre for Mass Spectrometry, Department of Analytical & Structural Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India
c   Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
,
a   Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India
c   Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
,
a   Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India
c   Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
› Author Affiliations


Abstract

A variety of aryne reactions are demonstrated in poly(ethylene glycol) dimethyl ethers (PEGDMEs) as solvents without the need of any additive. The reactions proceed efficiently and good yields of the desired products are observed with PEGDME. Further, the advantage of being able to recycle PEG solvents is demonstrated in this work.

Supporting Information



Publication History

Received: 23 March 2022

Accepted after revision: 09 May 2022

Accepted Manuscript online:
09 May 2022

Article published online:
20 June 2022

© 2022. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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