CC BY-NC-ND 4.0 · Z Gastroenterol 2023; 61(05): 489-503
DOI: 10.1055/a-1852-5713
Originalarbeit

Real‐world experience for the outcomes and costs of treating hepatitis C patients: Results from the German Hepatitis C-Registry (DHC-R)

Outcomes und Kosten der Behandlung von Hepatitis-C-Patienten in der medizinischen Praxis: Ergebnisse aus dem Deutschen Hepatitis-C-Register (DHC-R)
Kathrin Krüger
1   Institute for Epidemiology, Social Medicine and Health Systems Research, Hannover Medical School, Hannover, Germany (Ringgold ID: RIN9177)
,
Siegbert Rossol
2   Medizinische Klinik, Krankenhaus Nordwest, Frankfurt, Germany (Ringgold ID: RIN9152)
,
Christian Krauth
1   Institute for Epidemiology, Social Medicine and Health Systems Research, Hannover Medical School, Hannover, Germany (Ringgold ID: RIN9177)
,
Peter Buggisch
3   ifi-Institut für interdisziplinäre Medizin, Hamburg, Germany
,
Stefan Mauss
4   Center for HIV and Hepatogastroenterology, Duesseldorf, Germany
,
Albrecht Stoehr
3   ifi-Institut für interdisziplinäre Medizin, Hamburg, Germany
,
Hartwig Klinker
5   University Hospital Würzburg, Würzburg, Germany
,
Klaus Böker
6   Leberpraxis Hannover, Hannover, Germany
,
Gerlinde Teuber
7   MVZ Frankfurt, Frankfurt am Main, Germany
,
Jona Stahmeyer
1   Institute for Epidemiology, Social Medicine and Health Systems Research, Hannover Medical School, Hannover, Germany (Ringgold ID: RIN9177)
› Institutsangaben
The German Hepatitis C-Registry is financially supported by AbbVie Deutschland GmbH & Co. KG, Gilead Sciences GmbH, MSD Sharp & Dohme GmbH as well as Bristol-Myers Squibb GmbH & Co. KGaA and Janssen-Cilag GmbH (each until 2020-07-14) and Roche Pharma AG (until 2017-07-14).
 

Abstract

Background & Aims With long-term consequences like the development of liver cirrhosis and hepatocellular carcinoma, chronic hepatitis C virus (HCV) infection is associated with a significant health burden. Information on HCV treatment outcomes and costs in routine care is still rare, especially for subgroups. The aim of this study was to analyse the treatment outcomes and costs of subgroups in routine care and to compare them over time with previous analyses.

Methods Data were derived from a noninterventional study including a subset of 10298 patients receiving DAAs with genotypes 1 and 3. Sociodemographic, clinical parameters and costs were collected using a web-based data recording system. The total sample was subdivided according to treatment regimen, cirrhosis status as well as present HIV infection and opioid substitution treatment (OST).

Results 95% of all patients achieved SVR. Currently used DAA showed higher SVR-rates and less adverse events (AE) compared to former treatments. Concerning subgroups, cirrhotic patients, HIV-coinfected patients and OST patients showed lower but still high SVR-rates. In comparison, cirrhotic had considerably longer treatment duration and more frequent (serious) AE. Overall, average treatment costs were €48470 and costs per SVR were €51129; for currently used DAAs costs amounted to €30330 and costs per SVR to €31692. After the end of treatment, physical health is similar to the general population in all patients except cirrhotic. Mental health remains far behind in all subgroups, even for currently used DAA.

Conclusions Over time, some relevant factors developed positively (SVR-rates, costs, treatment duration, adverse events, health-related quality of life (HRQoL)). Further research on HRQoL, especially on mental health, is necessary to evaluate the differences between subgroups and HRQoL over time and to identify influencing factors.


#

Zusammenfassung

Hintergrund und Ziele Die chronische Infektion mit dem Hepatitis-C-Virus (HCV) ist mit Langzeitfolgen wie der Entwicklung einer Leberzirrhose oder eines hepatozellulären Karzinoms assoziiert und stellt eine erhebliche Gesundheitsbelastung dar. Informationen über HCV-Behandlungsergebnisse und -kosten in der Praxis sind nach wie vor rar, insbesondere für Subgruppen. Ziel dieser Studie war es, die Behandlungsergebnisse und -kosten von Subgruppen in der Versorgung zu analysieren und sie mit früheren Analysen zu vergleichen.

Methoden Die Daten stammen aus einer nicht interventionellen Studie mit einer Untergruppe von 10298 Patient*innen, die DAA erhalten und die Genotypen 1 und 3 aufweisen. Soziodemografische und klinische Parameter sowie Kosten wurden mithilfe eines webbasierten Datenerfassungssystems erhoben. Für die Analysen wurden verschiedene Subgruppen definiert: Die Gesamtstichprobe wurde nach Zirrhosestatus und nach vorhandener HIV-Infektion und Opioidsubstitutionsbehandlung (OST) unterteilt.

Ergebnisse 95 % aller Patienten erreichten eine SVR. Die derzeit verwendeten DAA wiesen im Vergleich zu früheren Behandlungen höhere SVR-Raten und weniger unerwünschte Ereignisse (AE) auf. Was die Untergruppen betrifft, so wiesen zirrhotische Patienten, HIV-Koinfizierte und OST-Patienten niedrigere, aber immer noch hohe SVR-Raten auf. Im Vergleich dazu hatten Zirrhotiker eine deutlich längere Behandlungsdauer und häufiger (schwere) Nebenwirkungen. Insgesamt beliefen sich die durchschnittlichen Behandlungskosten auf 48470 € und die Kosten pro SVR auf 51129 €; für die derzeit verwendeten DAAs beliefen sich die Kosten auf 30330 € und die Kosten pro SVR auf 31692 €. Nach Abschluss der Behandlung ist der körperliche Gesundheitszustand bei allen Patienten mit Ausnahme der Zirrhotiker mit dem der Allgemeinbevölkerung vergleichbar. Die psychische Gesundheit bleibt in allen Untergruppen weit zurück, selbst bei derzeit verwendeten DAA.

Schlussfolgerungen Im Laufe der Zeit entwickelten sich einige relevante Faktoren positiv (SVR-Raten, Kosten, Behandlungsdauer, unerwünschte Ereignisse, gesundheitsbezogene Lebensqualität [HRQoL]). Weitere Forschung zur HRQoL, insbesondere zur psychischen Gesundheit, ist erforderlich, um die Unterschiede zwischen den Subgruppen und die HRQoL im Zeitverlauf zu bewerten und Einflussfaktoren zu identifizieren.


#

Background and Aims

Hepatitis C is recognized as a disease of global importance since more than 170 million people worldwide are chronically infected with the hepatitis C virus (HCV) [1]. In Germany, survey data show an anti HCV-prevalence of 0.3% in the general population [2]. However, considering a higher prevalence in risk-groups such as drug abuser, prison inmates, and HIV co-infected patients, recent studies estimate 275000 chronically infected people [3].

Most HCV infections remain predominantly undiagnosed until severe, potentially lethal complications, like liver cirrhosis or hepatocellular carcinoma (HCC), occur in late and advanced stages of the disease, [4] [5]. Chronic HCV accounts for about a quarter of liver cirrhosis and HCC each [6] and, in addition, chronic hepatitis C is still one of the most common causes of liver transplantation [7]. Worldwide, 350000 people die each year from these long-term consequences of HCV infection [1].

Eradication of the HCV virus is associated with a decreased risk of liver cirrhosis, HCC, liver-related mortality and all-cause mortality, as well as an increase in health-related quality of life (HRQoL) in infected patients. Therefore, achieving sustained virological response (SVR) is the main goal of antiviral treatment of HCV infection [8] [9] [10]. Compared to the first-generation DAAs, boceprevir and telaprevir, and to earlier treatment regimens, the introduction of the second-generation direct-acting antivirals (DAAs) has significantly improved antiviral therapy for HCV infection. SVR rates significantly increased in all genotypes and subgroups up to 99% [11] [12]. Furthermore, second-generation DAAs have shorter treatment durations, favourable toxicity profiles and can also be used in patients who were not eligible for treatment in the past to age and other diseases besides HCV infection. Using these new regimens together with different nationwide screening strategies it will be feasible to achieve a nearly complete HCV eradication by the year 2030 [13] [14].

However, until now information on hepatitis C treatment outcomes and costs in routine care is rare, especially for subgroups. Therefore, the aim of this study was to analyze the outcomes and costs of treatment for HCV patients stratified by population and cirrhosis status in routine care and to compare them over time with previous analyses, using one of the largest databases worldwide generated by the German Hepatitis C-Registry (Deutsches Hepatitis C-Register; DHC-R) [15].


#

Methods

We analysed data acquired from the German Hepatitis C-Registry (Deutsches Hepatitis C-Register; DHC-R). With about 18400 patients currently, the DHC-R is one of the largest registries for HCV worldwide. It is a prospective, multicenter, real-world registry study and collects data on treatment-naive (TN) and treatment-experienced (TE) HCV patients in clinics and medical practices throughout Germany. Patient enrolment started in 2014 and ended in March 2022.

The DHC-R is a project of the German Liver Foundation (Deutsche Leberstiftung), managed by the Leberstiftungs-GmbH Deutschland in cooperation with the Association of German Gastroenterologists in Private Practice (Berufsverband Niedergelassener Gastroenterologen Deutschlands e.V.; bng) with financial support from the German Center for Infection Research (DZIF) and the companies AbbVie Deutschland GmbH & Co. KG, Gilead Sciences GmbH, MSD Sharp & Dohme GmbH as well as Bristol-Myers Squibb GmbH & Co. KGaA and Janssen-Cilag GmbH (each until 2020-07-14) and Roche Pharma AG (until 2017-07-14). The registry was approved by the Ethical Committee of Ärztekammer Westfalen-Lippe (No.: 2014-395-f-S). Furthermore, the DHC-R was announced to the Federal Institute for Drugs and Medical Devices (BfArM: 2493) and the German Clinical Trials Registry (DRKS: DRKS00009717).

Patients had to provide written informed consent before being enrolled in the study. Inclusion criteria were chronic HCV infection with detectable HCV-RNA as well as an age of 18 years or older. Exclusion criteria were pregnancy, nursing women or women of childbearing age without reliable contraception, as well as contraindications for use of antiviral treatment. Treatment choice was at the discretion of the physician. To date, data from the DHC-R have been published in different publications, providing detailed information on epidemiological data, treatment practice, healthcare utilization and outcomes in different subgroups [16] [17] [18] [19] [20] [21].

Data were gathered using a web-based data recording system. The quality of the data was assessed by on-site monitoring and automated plausibility checks. Data collection included sociodemographic parameters, clinical parameters, healthcare utilization (e.g. pharmaceuticals) and treatment outcomes (SVR) for all patients. SVR was assessed 12 weeks after treatment (SVR12). Pharmaceutical costs for the German market are based on the German price database Lauer Taxe with status February 2020 [22]. Nonpharmaceutical costs, for instance laboratory tests, imaging techniques and hospitalization, were not considered in the analysis of costs, as they are relatively low for current therapies. The calculation of costs and costs per SVR for the defined subgroups (i. e., subdivided by cirrhosis status, present HIV infection and opioid substitution treatment) stratified by treatment regimen could not be calculated exactly, only approximately, since for some values only aggregated data were available.

For some patients, quality of life (HRQoL) was also assessed on a voluntary basis. HRQoL was determined using the German version and transformation of the Short-Form-36, version 2 (SF-36v2) [23]. Patients were asked to complete the questionnaires at four different times: (i) baseline, (ii) treatment week 12, (iii) end of treatment, and (iv) 24 weeks after treatment.

In the preliminary phase of the present analysis, all required relevant variables were defined in a statistical analysis plan. The analysis is based on data from a defined subset of HCV patients with genotype (GT) 1 and 3 who initiated and finished treatment between February 2014 and December 2019. Genotype 1 and 3 represent the majority of infected patients in Germany and account for more than 90% of all infections. Data were analyzed as of January 1, 2020. For the analyses, different subgroups were defined:

  1. The total sample was subdivided according to cirrhosis status:

    • non-cirrhotic

    • cirrhotic

  2. The total sample was subdivided according to present HIV infection and opioid substitution treatment (OST):

    • persons who are neither HCV/HIV co-infected nor in OST (hereafter: non-HIV population)

    • HIV-infected and/or OST patients

In addition, the analyses were stratified according to the various treatment regimens. EBR/GZR, SOF/VEL, G/P and SOF/VEL/VOX are defined as currently used DAAs; all further treatments are referred to as previous treatments. In total, data from 10298 patients provided by 281 outpatient practices and hospital-based outpatient clinics were analyzed. Statistical analyses were carried out using IBM SPSS Statistics 21 (IBM Corporation, Armonk, New York, USA). They are primarily descriptive to reflect the noninterventional nature of the study. Subgroup analyses were carried out using the t-test or the χ2-test depending on the type of variable. Differences were considered significant at a level of p≤0.05.

Furthermore, the results were compared with those of a previous study, which also included data from the DHC-R collected between February 2014 and February 2017 [12].

All methods were carried out in accordance with relevant guidelines and regulations.


#

Results

Patient characteristics

A total of 10298 patients who met the inclusion criteria were included in the analyses. On average, the patients were 53 years old, 60% of them male. The mean weight was 77 kg, the mean height 173 cm, and the mean BMI 25,9 kg/m2. Almost all patients were Caucasian. The most common routes of transmission were intravenous drug use (30%) and blood or blood products (14%), although for 41% of patients the route of transmission was unknown. Transmission through intravenous drug use varied with respect to genotype (GT 1b: 11%; GT 3: 53%). At baseline, 87% of patients had a viral load of 6 million IU/ml or less, 12% had a viral load greater than 6 million IU/ml and 1% did not have their viral load analyzed.

Information on liver cirrhosis was mostly based on imaging techniques and elastography due to the non-interventional nature of the study. More than three-quarters of all patients received a sonographic examination of the liver. In total, one-third of the patients demonstrated liver cirrhosis at baseline. Child-Pugh score information was available for 2007 of these patients. A total of 1764 had stage A cirrhosis (indicating compensated liver function), 211 had stage B cirrhosis (indicating moderate liver function) and 32 had stage C cirrhosis (indicating poor liver function). At baseline, the mean aspartate aminotransferase to platelet ratio index score was 1.1. For 40% of the patients, the score was up to 0.5, for 40%, it was between 0.5 and 1.5, and for 20%, it was over 1.5.

Overall, 61% of patients were treatment-naïve. The most frequent treatment regimen was SOF/LDV (28%). Among GT 1a, GT 1b, and GT 1 patients, most received SOF/LDV (37%, 31%, and 47%, respectively), and among GT 3 patients, most received G/P (34%). Over three-quarters of the patients (76%) had one or more comorbidities. The most common comorbidities were cardiovascular disease (27%), psychiatric disorders (15%), diabetes mellitus (9%), and thyroid dysfunction (9%). A history of drug abuse and alcohol abuse was observed for 2166 (21%) and 552 (5%) patients, respectively. Patient characteristics are summarized in [Table 1].

Table 1 Patients characteristics at baseline.

Parameter

GT 1a

n=3598

GT 1b

n=4490

GT 1 unknown

n=297

GT 3

n=1913

All patients

n=10298

* Based on all available data.

Age, years (n=10298)

50.7

56.4

54.7

46.4

52.5

Sex, female (n=10298)

30.9%

51.9%

48.8%

28.0%

40.0%

Ethnicity (n=10298)

  • Caucasian

97.0%

97.7%

97.0%

96.4%

97.2%

  • African

1.2%

0.5%

1.0%

0.4%

0.7%

  • Asian

1.2%

1.6%

1.3%

2.7%

1.6%

  • Hispanic

0.7%

0.2%

0.7%

0.3%

0.4%

  • Other

0.0%

0.0%

0.0%

0.1%

0.0%

Height, cm (n=10298)

174.7

169.9

171.7

174.3

172.5

Weight, kg (n=10292)

78.1

75.8

76.6

79.2

77.2

Body-Mass-Index, kg/m2 (n=10292)

25.5

26.2

25.9

26.0

25.9

Duration of Infection, years (n=6826)

17.8

21.9

21.0

15.9

19.2

Route of Transmission (n=10298)

  • Blood or Blood Products

9.3%

20.8%

18.5%

5.3%

13.8%

  • Drug Abuse

43.6%

10.5%

20.9%

53.1%

30.2%

  • Sexual Transmission

10.5%

1.8%

5.1%

3.3%

5.2%

  • Surgical or Medical Treatment

3.5%

10.1%

8.4%

4.5%

6.7%

  • Other

2.2%

3.3%

3.4%

2.3%

2.7%

  • Unknown

31.0%

53.7%

43.8%

31.6%

41.3%

Treatment Status (n=10298)

  • naïve

58.9%

58.8%

45.1%

74.8%

61.4%

  • experienced

41.1%

41.2%

54.9%

25.2%

38.6%

Liver Cirrhosis* (n=10298)

33.9%

29.4%

35.0%

34.9%

32.5%

APRI-Score at Baseline (n=9265)

1.0

1.1

1.3

1.3

1.1

APRI-Score at Baseline (n=9265)

  • ≤ 0.5

1410

1630

94

537

3671

  • > 0.5–1.5

1283

1608

106

747

3744

  • > 1.5

537

790

57

466

1850

Baseline Viral Load IU/ml (n=10298)

4380255

2811421

3955026

3120391

3450838

Baseline Viral Load (n=10298)

  • ≤ 6 million IU/ml

83.7%

89.4%

86.2%

85.3%

86.6%

  • > 6 million IU/ml

15.1%

8.9%

13.1%

14.1%

12.2%

  • unknown

1.2%

1.6%

0.7%

0.6%

1.3%

Child-Pugh Score (n=3348)

  • Unknown

39.1%

40.7%

42.3%

39.7%

40.1%

  • A

53.5%

52.5%

47.1%

52.8%

52.7%

  • B

6.6%

5.9%

8.7%

6.4%

6.3%

  • C

0.9%

0.9%

1.9%

1.0%

1.0%

Comorbiditiy (n=10298)

  • no

18.9%

27.2%

25.6%

25.8%

24.0%

  • yes

81.1%

72.8%

74.4%

74.2%

76.0%

Treatment regimen (n=10298)

  • SOF+RBV

0.4%

0.4%

1.3%

14.5%

3.1%

  • SOF+IFN+RBV

4.4%

3.5%

4.7%

10.1%

5.1%

  • SMV+IFN+RBV

0.0%

0.1%

0.0%

0.1%

0.0%

  • SOF+SMV

2.4%

4.1%

4.0%

0.0%

2.7%

  • SOF+SMV+RBV

0.4%

0.6%

1.0%

0.0%

0.4%

  • SOF+DCV

6.3%

6.3%

11.8%

15.0%

8.1%

  • SOF+DCV+RBV

0.5%

0.6%

1.7%

6.3%

1.7%

  • SOF/LDV

37.1%

31.2%

46.8%

0.8%

28.0%

  • SOF/LDV+RBV

8.3%

6.2%

10.1%

5.2%

6.8%

  • OBV/PTV/r+DSV

0.9%

14.3%

2.4%

0.0%

6.6%

  • OBV/PTV/r+DSV+RBV

8.5%

4.5%

3.0%

0.0%

5.0%

  • EBR/GZR

7.8%

19.9%

3.7%

0.0%

11.5%

  • SOF/VEL

3.8%

1.2%

1.3%

12.3%

4.2%

  • G/P

18.0%

6.4%

7.7%

33.8%

15.6%

  • SOF/VEL/VOX

1.3%

0.8%

0.3%

1.9%

1.2%


#

Treatment response and duration

The overall SVR-rate was 95% (n=9761). Of the remaining patients, 189 (1.8%) were lost to follow-up and 348 (2.4%) achieved no SVR because of different reasons: 15 showed no response at the end of therapy (0.1%), 244 developed a relapse at the end of therapy (2.4%), 27 showed a reinfection (0.3%), and 62 were still HCV RNA qualitative positive (0.6%) at 12 weeks after the end of treatment.

The average length of treatment was 12 weeks (SD: 4.5 weeks) and varies between treatment regimen, cirrhosis-status and subpopulation. Cirrhotic patients show a longer treatment duration than non-cirrhotic patients (14.4 vs. 11.0, p≤ 0.001) and HIV-infected and/or OST patients show a shorter duration compared to non-HIV population (11.5 vs. 12.2, p≤ 0.001).

Considering the overall SVR rate of 95%, depending on the treatment regimen, the SVR rates varied from 77 up to 97%. Highest SVR rates were observed for SOF/LDV (96.9%), SOF/VEL/VOX (96.7%), G/P (96.4%), EBR/GZR (96.1%), and OBV/PTV/r+DSV (96.0%). The SVR rate was 96% in noncirrhotic patients and 93% in cirrhotic patients (p≤ 0.001). In terms of subpopulations, the SVR rate among the HIV-infected and/or OST patients is 93% while for the non-HIV population it is 95% (p≤ 0.001). Further information on response rates and treatment duration is summarized in [Table 2].

Table 2 Treatment outcomes by patient group.

Treatment outcome

Patient group

n

Treatment duration, weeks

SVR

No SVR*

Lost to follow-up, not tested, %

* Patients with nonresponse, reinfection, relapse or still qualitative positive patients (/> 25 IU/ml nnb).

** No data on SMV+IFN+RBV due to a small number of cases (n=5).

Treatment regimen**

SOF+RBV

315

22.8

77.1%

16.6%

6.3%

SOF+IFN+RBV

525

12.5

91.0%

8.0%

1.0%

SOF+SMV

282

12.2

93.3%

6.7%

0.0%

SOF+SMV+RBV

43

13.4

90.7%

7.0%

2.3%

SOF+DCV

832

15.2

94.4%

3.4%

2.2%

SOF+DCV+RBV

171

19.7

93.0%

2.9%

4.1%

SOF/LDV

2888

11.1

96.9%

1.7%

1.4%

SOF/LDV+RBV

705

14.9

93.6%

4.7%

1.7%

OBV/PTV/r+DSV

679

11.6

96.0%

2.7%

1.3%

OBV/PTV/r+DSV+RBV

515

12.4

94.0%

2.7%

3.3%

EBR/GZR

1183

12.0

96.1%

2.8%

1.1%

SOF/VEL

430

11.9

91.9%

4.4%

3.7%

G/P

1605

8.4

96.4%

1.7%

1.9%

SOF/VEL/VOX

120

11.9

96.7%

2.5%

0.8%

Cirrhosis status

Non-cirrhotic

6950

11.0

95.9%

2.8%

1.7%

Cirrhotic

3348

14.4

92.5%

2.3%

2.2%

Subpopulations

Non-HIV population

8423

12.2

95.2%

3.3%

1.5%

HIV infected and/or OST patients

1875

11.5

92.9%

3.8%

3.3%

Overall

10298

12.1

94.8%

3.4%

1.8%


#

Safety summary and adverse events during treatment

Non-serious adverse events (AE) were observed in 50% of the treated patients. The most common non-serious AEs were fatigue [2131 (20.7%) patients], headache [1348 (13.4%) patients], nausea [607 (5.9%) patients], insomnia [508 (4.9%) patients], pruritus [463 (4.5%) patients], arthralgia [453 (4.4%) patients], and abdominal complaints [433 (4.2%) patients]. Serious AE were relatively few in our sample. Overall, 4.0% of patients had at least one serious AE. The most frequent serious AE was malignant neoplasm of the liver [34 (0.3%) patients]. 1.0% of the patients discontinued therapy because of AE. In terms of treatment regimen, the currently used DAAs showed fewer AE, serious AE, and treatment discontinuations due to non-serious AE/serious AE compared to previous treatments (see [Table 3]).

Table 3 Safety summary by patient group.

Patient group

n

Dosis reduction

AE

Serious AE

Death

Therapy discontinuation due to AE/SAE

* No data on SMV+IFN+RBV due to a small number of cases (n=5).

Treatment regimen*

SOF+RBV

315

23 (7.3%)

220 (69.8%)

19 (6.0%)

1 (0.3%)

5 (1.6%)

SOF+IFN+RBV

525

56 (10.7%)

396 (75.4%)

18 (3.4%)

0 (0.0%)

14 (2.7%)

SOF+SMV

282

1 (0.4%)

182 (64.5%)

36 (12.8%)

3 (1.1%)

2 (0.7%)

SOF+SMV+RBV

43

2 (4.7%)

33 (76.7%)

6 (14.0%)

0 (0.0%)

3 (7.0%)

SOF+DCV

832

1 (0.1%)

478 (57.5%)

35 (4.2%)

3 (0.4%)

6 (0.7%)

SOF+DCV+RBV

171

10 (5.8%)

141 (82.5%)

25 (14.6%)

5 (2.9%)

9 (5.3%)

SOF/LDV

2888

3 (0.1%)

1379 (47.7%)

109 (3.8%)

15 (0.5%)

11 (0.4%)

SOF/LDV+RBV

705

74 (10.5%)

508 (72.1%)

51 (7.2%)

5 (0.7%)

21 (3.0%)

OBV/PTV/r+DSV

679

1 (0.1%)

345 (50.8%)

20 (2.9%)

4 (0.6%)

4 (0.6%)

OBV/PTV/r+DSV+RBV

515

53 (10.3%)

351 (68.2%)

23 (4.5%)

1 (0.2%)

20 (3.9%)

EBR/GZR

1183

1 (0.1%)

428 (36.2%)

28 (2.4%)

3 (0.3%)

2 (0.2%)

SOF/VEL

430

0 (0.0%)

148 (34.4%)

12 (2.8%)

2 (0.5%)

1 (0.2%)

G/P

1605

2 (0.1%)

446 (27.8%)

25 (1.6%)

3 (0.2%)

2 (0.1%)

SOF/VEL/VOX

120

0 (0.0%)

55 (45.8%)

7 (5.8%)

1 (0.8%)

0 (0.0%)

Cirrhosis status

Non-cirrhotic

6950

83 (1.2%)

3096 (44.5%)

171 (2.5%)

17 (0.2%)

36 (0.5%)

Cirrhotic

3348

145 (4.3%)

2019 (60.3%)

244 (7.3%)

29 (0.9%)

65 (1.9%)

Subpopulations

non-HIV population

8423

191 (2.3%)

4223 (50.1%)

311 (3.7%)

34 (0.4%)

83 (1.0%)

HIV infected and/or OST patients

1875

37 (2.0%)

892 (47.6%)

104 (5.5%)

12 (0.6%)

18 (1.0%)

Overall

10298

228 (2.2%)

5115 (49.7%)

415 (4.0%)

46 (0.4%)

101 (1.0%)

Differences of the incidence of non-serious and serious AE may be due to different patient characteristics, such as a different proportion of cirrhotic patients. [Table 3] summarizes the safety summary stratified by treatment regimens, cirrhosis status, and subpopulation. Serious AE and death were more frequent in cirrhotic compared to non-cirrhotic patients (p≤ 0.001) as well as in HIV-infected and/or OST patients compared to the non-HIV population (p≤ 0.001). Therapy discontinuation due to non-serious AE/serious AE differs regarding cirrhosis-status (p≤ 0.001), while there was no significant difference with respect to subpopulation (p= 0.920).


#

Pharmaceutical costs and costs per SVR

The average pharmaceutical costs amounted to €48470 for the entire observation period. Regarding treatment regimens, it is obvious that the costs of the currently used DAAs (EBR/GZR, SOF/VEL, G/P, SOF/VEL/VOX) differed significantly from those of the former treatment regimens; the average costs of the newer therapies were €30330, while that of the former therapies were €57171. In terms of cirrhosis status, costs for the currently used treatment of non-cirrhotic patients amounted to €30242 (former treatments: €49477) and that for cirrhotic patients amounted to €30597 (former treatments: €70727). The non-HIV population had overall costs of €30151 (former treatments: €57634) and HIV-infected and/or OST patients had overall costs of €30916 (former treatments: €54692).

The average costs per patient who achieved an SVR were calculated on the basis of SVR rates and cost estimates in different patient groups. The average costs per SVR with currently used DAAs were €31535 (former treatments: €51592) in non-cirrhotic and €33077 (former treatments: €76461) in cirrhotic. Average costs per SVR of €31672 (former treatments: €60540) and €33279 (former treatments: €58872) were calculated for the non-HIV population and HIV-infected and/or OST patients, respectively. Overall, the average costs per SVR of the treatments currently used was €31692, compared with €60626 for previous therapies. Treatment costs and costs per SVR estimates are presented in [Table 4].

Table 4 Pharmaceutical costs and costs per SVR estimates by patient group.

n

Treatment costs, €

SVR

Costs per SVR, €

* Only currently used DAA regimens are considered individually.

Treatment regimen*

EBR/GZR

1183

26000.19

96.1%

27055.35

SOF/VEL

430

29740.21

91.9%

32361.49

G/P

1605

31489.63

96.4%

32665.59

SOF/VEL/VOX

120

59607.96

96.7%

61642.15

Overall: Currently used DAA

3338

30329.60

95.7%

31692.37

Overall: Treatments no longer/barely used (as of 02/2022)

6960

57170.60

94.3%

60626.30

Cirrhosis status

Non-cirrhotic

6950

42529.78

95.9%

44348.05

Currently used DAA

2510

30241.55

31534.47

Treatments no longer/barely used (as of 02/2022)

4440

49476.50

51591.76

Cirrhotic

3348

60802.20

92.5%

65732.10

Currently used DAA

828

30596.64

33077.45

Treatments no longer/barely used (as of 02/2022)

2520

70726.88

76461.49

Subpopulations

Non-HIV population

8423

49281.47

95.2%

51766.25

Currently used DAA

2560

30151.42

31671.66

Treatments no longer/barely used (as of 02/2022)

5863

57634.35

60540.28

HIV infected and/or OST patients

1875

44826.60

92.9%

48252.53

Currently used DAA

778

30916.03

33278.83

Treatments no longer/barely used (as of 02/2022)

1097

54692.07

58871.98

Overall

10298

48470.36

94.8%

51129.07


#

Health-related quality of life

Complete information on health-related quality of life (HRQoL) was not available for the total population as some patients did not complete the questionnaires or did not participate at all in three included measurement time points (baseline, end of treatment, 24 weeks post=treatment). For this reason, three different sub-samples were used to perform our analyses and to include all patients available:

  1. HRQoL of infected patients (baseline analysis)

  2. Development of HRQoL during treatment (complete data analysis)

  3. Differences in HRQoL depending on SVR (post-treatment analysis)

At baseline, a total of 4472 out of 10298 patients filled out the questionnaire regarding HRQoL. One result of the analysis was that HCV-infected patients had lower scores regarding all scores of the SF-36 subscales compared to the general population in Germany. The most significant differences were observed for role-emotional (–23), role-physical (–19), and social functioning (–16). With respect to the two summary scores of the SF-36, there was a large difference for the mental component summary score between HCV patients and the general population (40 vs. 51), while the physical component summary scores were almost similar (48 vs. 50). Considering the subgroups, it is obvious that there was a difference between cirrhotic and non-cirrhotic patients as well as between HIV-infected and/or OST patients and the non-HIV HCV-infected population. In terms of cirrhosis status, a greater difference was observed on the physical component summary score (PCS: 44 vs. 49; MCS: 39 vs. 41), whereas in terms of subpopulations, a greater difference was seen on the mental component summary score (PCS: 48 vs. 47; MCS: 37 vs. 41). An unexpected result in this context is that the HIV-infected and/or OST patients showed a higher physical component summary score than the non-HIV HCV-infected population. SF-36 baseline results by subgroup are shown in [Table 5].

Table 5 SF-36 baseline results.

CIRRHOSIS-STATUS

SUBPOPULATIONS

Total

German norm population

Diff

Non-cirrhotic

Cirrhotic

Non-HIV population

HIV infected and/or OST patients

SF-36 scales

n

Mean

SD

n

Mean

SD

n

Mean

SD

n

Mean

SD

n

Mean

SD

Mean

SD

Physical functioning

3144

81

22.9

1328

70

26.2

3566

77

24.9

906

80

22.7

4472

78

24.5

86

22.3

8

Role-physical

3144

69

39.3

1328

53

42.5

3566

65

40.7

906

61

41.5

4472

64

40.9

83

32.6

19

Bodily pain

3144

76

26.9

1328

67

28.4

3566

74

28.0

906

73

26.4

4472

73

27.6

79

27.4

6

General health

3144

57

20.5

1328

49

20.4

3566

55

20.9

906

52

20.1

4472

55

20.7

68

20.3

13

Vitality

3144

49

21.0

1328

45

21.4

3566

49

21.5

906

44

19.4

4472

48

21.2

63

18.5

15

Social functioning

3144

74

25.2

1328

70

25.9

3566

74

25.4

906

69

25.4

4472

73

25.5

89

18.4

16

Role-emotional

3144

70

40.9

1328

60

44.0

3566

69

41.5

906

60

43.8

4472

67

42.1

90

26.3

23

Mental health

3144

63

19.6

1328

61

19.6

3566

64

19.7

906

58

18.7

4472

63

19.6

74

16.6

11

Sum scores:

Physical component summary score

3144

49

9.2

1328

44

10.0

3566

47

9.9

906

48

9.1

4472

48

9.7

50

10.3

2

Mental component summary score

3144

41

13.7

1328

39

13.9

3566

41

13.7

906

37

13.7

4472

40

13.8

51

8.2

11

To analyze the development of quality of life during antiviral treatment, three measurement points (baseline, end of treatment, and approximately 24 weeks post-treatment) were analyzed. Cases for which baseline data were available were included for this analysis. Data are not available for all of these cases at the other two measurement points:

  • Baseline (n=4472)

  • End of treatment (n=2579)

  • Post-treatment (n=2135)

The present analysis showed an increase of the physical component summary score in all subgroups, whereas the increase was almost comparable between baseline and pos-t treatment: cirrhotic (+3), non-cirrhotic (+2), HIV-infected and/or OST patients (+3), non-HIV population (+3). The same applies to the mental component summary score, where the values also increased to a similar extent: cirrhotic (+4), non-cirrhotic (+5), HIV-infected and/or OST patients (+4), non-HIV population (+5). Development of quality of life in physical component summary score and mental component summary score is described in [Fig. 1] and [Fig. 3] for cirrhosis status and [Fig. 2] and [Fig. 4] for sub-populations.

Zoom Image
Fig. 1 Physical component summary score over time and reference values from German norm population, stratified by cirrhosis status.
Zoom Image
Fig. 2 Physical component summary score over time and reference values from German norm population, stratified by sub-population.
Zoom Image
Fig. 3 Mental component summary score over time and reference values from German norm population, stratified by cirrhosis status.
Zoom Image
Fig. 4 Mental component summary score over time and reference values from German norm population, stratified by sub-population.

To determine the impact of SVR on quality of life, post-treatment data were analyzed. In total, 2646 patients filled out the quality of life questionnaire post-treatment. A comparison of patients who achieved SVR and those who failed treatment demonstrates that achievement of SVR was associated with an increased HRQoL. All SF-36 subscales showed higher values. Differences in HRQoL were greatest in role-physical (10) and role-emotional (15). The physical component summary score and the mental component summary score varied by 2 and 4, respectively. Average scores for patients with and without SVR post-treatment are shown in [Table 6]. Furthermore, the influence of treatment regimens and subgroups on HRQoL after the end of treatment was analyzed. With regard to treatment regimens, it was found that the currently used DAAs and the former treatments showed, on average, the same physical and mental component summary scores at the end of treatment (PCS: 49; MCS: 43). On the PCS, values were similar to those of the German norm population; individuals treated with G/P even had minimally higher values. In contrast, the values on the MCS were far below the average of the German norm population for both the previous and the currently used treatments. While higher values were recorded on PCS and MCS for non-cirrhotic compared to cirrhotic, the HIV- infected and/or OST patients showed minimally higher values on the PCS and considerably lower values on the MCS compared to the non-HIV population (see [Table 7]).

Table 6 Post-treatment HRQoL – SVR vs. no SVR.

No SVR

SVR

p-value

Total

SF-36 scales

n

Mean

SD

n

Mean

SD

n

Mean

SD

Physical functioning

73

75

25.4

2573

80

23.9

p=0.079

2646

80

24.0

Role-physical

73

60

42.2

2573

70

38.6

p=0.030

2646

70

38.8

Bodily pain

73

75

26.5

2573

78

26.5

p=0.340

2646

78

26.5

General health

73

54

16.6

2573

62

19.3

p≤0.001

2646

61

19.3

Vitality

73

48

19.6

2573

52

20.5

p=0.100

2646

52

20.4

Social functioning

73

70

23.6

2573

77

23.9

p=0.014

2646

77

24.0

Role-emotional

73

58

44.4

2573

73

39.8

p=0.002

2646

72

40.0

Mental health

73

64

18.5

2573

67

18.5

p=0.172

2646

67

18.5

Sum scores:

Physical component summary score

73

47

9.5

2573

49

9.2

p=0.067

2646

49

9.2

Mental component summary score

73

39

13.4

2573

43

13.0

p=0.010

2646

43

13.0

Table 7 Post-treatment HRQoL sum scores by patient group.

Patient group

n

Physical component

summary score

Diff. to German norm population (Mean 50; SD: 10.3)

Mental component summary score

Diff. to German norm population (Mean 51; SD: 8.2)

Mean

SD

Mean

SD

* only currently used DAA regimens are considered individually).

Treatment regimen*

EBR/GZR

387

48

10.1

2

44

12.7

7

SOF/VEL

110

49

9.0

1

41

13.0

10

G/P

425

51

8.5

–1

43

12.1

8

SOF/VEL/VOX

44

49

9.7

1

44

13.2

7

Overall: Currently used DAA

966

49

9.2

1

43

12.5

8

Overall: Treatments no longer/barely used (as of 02/2022)

1613

49

9.0

1

43

13.1

8

Cirrhosis status

Non-cirrhotic

1814

50

8.5

0

43

12.9

8

Cirrhotic

765

46

10.0

4

42

13.2

9

Subpopulations

Non-HIV population

2039

49

9.4

1

44

12.8

7

HIV infected and/or OST patients

540

50

8.3

0

40

13.4

11

Overall

2579

49

9.2

1

43

13.0

8

To analyze the transferability of HRQoL estimates, we compared patient characteristics (sex, age, cirrhosis-status) of patients with and without data on HRQoL. There was no significant difference regarding cirrhosis-status (p = 0.142), while age (p < 0.001) and sex (p < 0.001) differed significantly.


#
#

Discussion

Based on data from the German Hepatitis C-Registry, a large ongoing, non-interventional, multicenter, prospective, observational cohort study, the outcomes and costs of 10298 chronically infected hepatitis C patients were analyzed. The focus was on identifying differences by population and cirrhosis status. Regarding subpopulation, 1875 were HIV-infected and/or OST patients (18%), therefore the remaining 8423 formed the non-HIV and non-OST HCV-infected population of this study (82%). In terms of cirrhosis status, 6950 of the 10298 HCV-infected were non-cirrhotic (67%) and 3348 were cirrhotic (33%). We identified several differences but also similarities between the subgroups.

Treatment response and duration

Overall, we observed an SVR rate of 95% in our study population. A previous analysis of the registry data (02/2014–02/2017) showed a rate of 94% [12]. The SVR rate varies concerning treatment regimen, cirrhosis status (96% in non-cirrhotic patients and 93% in cirrhotic patients) and in terms of subpopulations (93% in HIV-infected and/or OST patients and 95% in the non-HIV population). This tendency is consistent with several other studies, which also show lower, but still high SVR-rates for cirrhotic patients, HIV-coinfected patients and OST patients treated with DAAs [24] [25] [26]. The average length of treatment was 12 weeks and is comparatively lower compared to 13 weeks in the prior analysis. Concerning subgroups, cirrhotic patients show a longer treatment duration than non-cirrhotic patients (14.4 vs. 11.0 weeks), which can be predominantly explained by medical necessity [27]. Furthermore, HIV-infected and/or OST patients show a shorter duration compared to non-HIV population (11.5 vs. 12.2 weeks), Higher treatment duration in the non-HIV population compared to HIV-infected and/or OST patients are explained by the different genotypes of the two subgroups and the resulting variation in treatment regimens, which are associated with different treatment durations [27] [28].


#

Safety summary and adverse events during treatment

Adverse events (AE) may occur during HCV treatment. While previous German real-world studies showed that 70–90% of patients receiving interferon-containing regimens had at least one non-severe AE and 4–11% had a severe AE during treatment [29] [30], recent studies in patients receiving predominantly interferon-free regimens show non-severe AE (58%) and severe AE (3%) less frequently, confirming better tolerability of interferon-free regimens [12]. In our sample, which received predominantly interferon-free regimens, non-severe AE occurred in half of the sample and severe AE in 4%. Regarding subgroups, the incidence of non-severe and severe AE varies between the non-HIV population and the group of HIV-infected and/or OST patients, as well as between non-cirrhotic and cirrhotic patients.


#

Pharmaceutical costs and costs per SVR

The average pharmaceutical costs summed up to €48470, in a previous analysis (02/2014–02/2017) the costs amounted to €67131 [12]. The costs vary between cirrhosis-status (€42530 for non-cirrhotic and €60802 for cirrhotic) and sub-populations (€49282 for non-HIV- population and €44827 for HIV=infected and/or OST patients). With the introduction of DAAs in 2011, overall SVR-rates have increased continuously over time, while costs have also risen initially [29] [30]. Since our previous analysis (02/2014–02/2017), however, costs have now fallen due to a shorter treatment duration and lower pharmaceutical prices. This is also confirmed by the significantly lower costs per SVR (€69840 vs. €51129) [31]. The price development becomes even more apparent if only the costs of the currently used treatment regimens (EBR/GZR, SOF/VEL, G/P, SOF/VEL/VOX) are considered. Overall, the costs for these DAAs are €30330 and the cost per SVR amounts to €31792. This trend applies to both non-cirrhotics and cirrhotics, as well as to the non-HIV population and HIV-infected and/or OST patients. Concerning subgroups, the average costs per SVR were €44348 (currently used DAAs: €31535; former treatments: €51592) in non-cirrhotic and €65732 (currently used DAAs: €33078; former treatments: €76462) in cirrhotic. Average costs per SVR of €51766 (currently used DAAs: €31672; former treatments: €60540) and €48253 (currently used DAAs: €33279; former treatments: €58872) were calculated for the non-HIV population and HIV-infected and/or OST patients, respectively. The higher pharmaceutical costs and costs per SVR in cirrhotic compared to non-cirrhotic can be primarily attributed to the longer treatment duration [25]. Higher costs in the non-HIV population compared to HIV-infected and/or OST patients are also due to the different genotypes and the associated different treatment regimens and treatment duration, as described above [27] [28]. However, for all subgroups, the costs per SVR are much lower in relation to the DAAs currently used compared to the previous treatments, ranging from €31535 to €33279.


#

Health-related quality of life

Compared to the general population in Germany, all scores in SF-36 subscales showed lower values in HCV-patients. The same applies to an earlier analysis [12]. In terms of cirrhosis status, a greater difference is seen on the PCS (PCS: 44 vs. 49; MCS: 39 vs. 41), whereas in terms of subpopulations, a greater difference is seen on the MCS (PCS: 48 vs. 47; MCS: 37 vs. 41). The higher score of HIV-infected and/or OST patients compared to non-HIV population on the PCS could be due to the fact that this group is younger on average. A younger age is associated with a higher quality of life. Differences between cirrhotic and non-cirrhotic in HRQoL can be explained by the disease itself; liver cirrhosis is associated with a further decline in HRQoL as the stage progresses [32] [33].

Over time, the analysis shows an increase of the PCS and MCS in all subgroups. With the exception of cirrhotic, the PCS in all subgroups reaches at least the value of the general population after 24 weeks, while the MCS is not reached by any subgroup and remains far behind the general population. The low value on the MCS in our sample cannot be confirmed by the literature. Studies on HRQoL in HCV-infected people in other countries show much higher MCS at baseline and after treatment compared to our sample [34] [35].


#

Limitations

The study has some known limitations associated with uncontrolled, observational, retrospective studies. Patients were recruited by the study sites based on their availability and willingness to participate, and thus were not randomly selected for participation, which could lead to response bias. However, due to the large patient sample, a potential bias can be considered low. Another limitation could be that not all data are available for all patients, as the documentation of all treatments and monitoring is at the discretion of the treating physicians. Moreover, the calculation of costs and costs per SVR for the subgroups stratified by treatment regimen could not be calculated exactly, but only approximately.

These limitations are in contrast to several strengths of our study, such as the large patient sample, detailed information on patient characteristics, a quality assurance system for data collection and, particularly, a large number of study centers throughout Germany that reflect routine care in daily practice.


#
#

Conclusions

Overall, some relevant factors developed positively in comparison to our previous analysis: SVR-rates slightly increased (2014–2017: 94%; 2014–2019: 95%), costs (2014–2017: €67131; 2014–2019: €48470) and treatment duration (2014–2017: 12.9 weeks; 2014–2019: 12.1 weeks) decreased, especially for currently used DAAs, and non-severe adverse events occurred less often (2014–2017: 58%; 2014–2019: 50%) [12]. In addition, a positive effect of treatment with DAAs on HRQoL was confirmed, but a difference between the general population and HCV-infected still remains after 24 weeks in cirrhotic regarding the PCS and in all subgroups concerning the MCS. However, the strength varies depending on the subgroup and the several items of the SF-36. Further research on HRQoL of DAAs, especially on MCS, is necessary to evaluate the association between subgroups and HRQoL over time and to identify influencing factors.

With respect to the described differences between non-cirrhotic and cirrhotic as well as between non-HIV population and HIV-infected and/or OST patients, further studies are also needed to identify predictors that help to further explain this gap.


#

Contributorsʼ Statement

Uta Merle, Renate Heyne, Tobias Müller, Rainer Günther, Ralph Link, Christine John, Marcus-Alexander Wörns, Uwe Naumann, Karl-Georg Simon, Markus Cornberg, Stefan Christensen, Thomas Lutz, Marc Ringelhan, Hjördis Möller, Michael Priller, Rainer Ullrich, Ansgar Rieke, Holger Hinrichsen, Tobias Goeser, Axel Baumgarten, Thomas Berg, Gudrun Hilgard, Kilian Weigand, Gerd Klausen, Stefan Zeuzem, Christoph Antoni, Dietrich Hüppe, Maria-Christina Jung, Andreas Schober, Andreas Weber, Heinz Hartmann, Michael P. Manns, Claus Niederau, Ulrike Protzer, Christoph Sarrazin, Peter Schirmacher, Heiner Wedemeyer


#
#

Conflict of Interest

The authors declare that they have no conflict of interest.

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  • 19 Dultz G, Müller T, Petersen J. et al. Effectiveness and Safety of Direct-Acting Antiviral Combination Therapies for Treatment of Hepatitis C Virus in Elderly Patients: Results from the German Hepatitis C Registry. Drugs Aging 2018; 35: 843-857 DOI: 10.1007/s40266-018-0572-0. (PMID: 30084012)
  • 20 Höner zu Siederdissen C, Schlevogt B, Solbach P. et al. Real-world effect of ribavirin on quality of life in HCV-infected patients receiving interferon-free treatment. Liver Int 2018; 38: 834-841 DOI: 10.1111/liv.13601. (PMID: 28960793)
  • 21 Tacke F, Boeker KH, Klinker H. et al. Baseline risk factors determine lack of biochemical response after SVR in chronic hepatitis C patients treated with DAAs. Liver Int 2019; 40: 539-548 DOI: 10.1111/liv.14186. (PMID: 31241820)
  • 22 LAUER-FISCHER GmbH. Lauer-Taxe Online/German Drug Directory. 2020
  • 23 Bullinger M, Kirchberger I. Der SF- 36 Fragebogen zum Gesundheitszustand – Handanweisung. Göttingen: Horgrefe; 1998
  • 24 Montes ML, Olveira A, Ahumada A. et al. Similar effectiveness of direct-acting antiviral against hepatitis C virus in patients with and without HIV infection. AIDS 2017; 31: 1253-1260 DOI: 10.1097/QAD.0000000000001465. (PMID: 28358742)
  • 25 Graf C, Mücke MM, Dultz G. et al. Efficacy of Direct-acting Antivirals for Chronic Hepatitis C Virus Infection in People Who Inject Drugs or Receive Opioid Substitution Therapy: A Systematic Review and Meta-analysis. Clinical Infectious Diseases 2020; 70: 2355-2365 DOI: 10.1093/cid/ciz696. (PMID: 31513710)
  • 26 Macken L, Gelson W, Priest M. et al. Efficacy of direct-acting antivirals: UK real-world data from a well-characterised predominantly cirrhotic HCV cohort. J Med Virol 2019; 91: 1979-1988 DOI: 10.1002/jmv.25552. (PMID: 31329295)
  • 27 Zimmermann T, Jansen P, Sarrazin C. et al. S3-Leitlinie „Prophylaxe, Diagnostik und Therapie der Hepatitis-C-Virus (HCV) -Infektion“. Z Gastroenterol 2018; 56: e53-e115 DOI: 10.1055/a-0598-5242. (PMID: 29986357)
  • 28 Simon KG, Serfert Y, Buggisch P. et al. Hepatitis C-Register D: Evolution of hepatitis C virus genotype 1a vs. 1b distribution reflects profound changes of HCV epidemiology in Germany between 2004 and 2018 – Analysis of 17093 patients from five consecutive registries including the German Hepatitis C-Registry (DHC-R).
  • 29 Stahmeyer JT, Krauth C, Bert F. et al. Costs and outcomes of treating chronic hepatitis C patients in routine care – results from a nationwide multicenter trial. Journal of Viral Hepatitis 2015; 23: 105-115 DOI: 10.1111/jvh.12471. (PMID: 26411532)
  • 30 Stahmeyer JT, Rossol S, Bert F. et al. Outcomes and Costs of Treating Hepatitis C Patients in the Era of First Generation Protease Inhibitors – Results from the PAN Study. PloS one 2016; 11: e0159976 DOI: 10.1371/journal.pone.0159976. (PMID: 27467772)
  • 31 Krüger K, Krauth C, Rossol S. et al. Outcomes and costs of treating hepatitis C patients with second-generation direct-acting antivirals: results from the German Hepatitis C-registry. European Journal of Gastroenterology & Hepatology 2018; DOI: 10.1097/MEG.0000000000001283.
  • 32 Siebert U, Ravens-Sieberer U, Greiner W. et al. Performance of different utility assessment methods in chronic hepatitis C patients. In Proceedings of the 19th Plenary Meeting of the EuroQol Group 13th-14th September 2002 Discussion Papers. In: Kind P, Macran S. . York: UK Centre for Health Economics; 2003: 175-184
  • 33 Stahmeyer JT, Rossol S, Liersch S. et al. Cost-Effectiveness of Treating Hepatitis C with Sofosbuvir/Ledipasvir in Germany. PLoS ONE 2017; 12: e0169401 DOI: 10.1371/journal.pone.0169401. (PMID: 28046099)
  • 34 Kracht PM, Lieveld FI, Amelung LM de. et al. The Impact of Hepatitis C Virus Direct-Acting Antivirals on Patient-Reported Outcomes: A Dutch Prospective Cohort Study. Infect Dis Ther 2018; 7: 373-385 DOI: 10.1007/s40121-018-0208-z. (PMID: 30076582)
  • 35 Jang ES, Kim YS, Kim K. et al. Factors Associated with Health-Related Quality of Life in Korean Patients with Chronic Hepatitis C Infection Using the SF-36 and EQ-5D. Gut and Liver 2018; 12: 440-448 DOI: 10.5009/gnl17322. (PMID: 29588435)

Correspondence

Kathrin Krüger
Institute for Epidemiology, Social Medicine and Health Systems Research, Hannover Medical School
Carl-Neuberg-Str. 1
30625 Hannover
Germany   

Publikationsverlauf

Eingereicht: 29. Oktober 2021

Angenommen nach Revision: 15. April 2022

Artikel online veröffentlicht:
15. Juli 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • 20 Höner zu Siederdissen C, Schlevogt B, Solbach P. et al. Real-world effect of ribavirin on quality of life in HCV-infected patients receiving interferon-free treatment. Liver Int 2018; 38: 834-841 DOI: 10.1111/liv.13601. (PMID: 28960793)
  • 21 Tacke F, Boeker KH, Klinker H. et al. Baseline risk factors determine lack of biochemical response after SVR in chronic hepatitis C patients treated with DAAs. Liver Int 2019; 40: 539-548 DOI: 10.1111/liv.14186. (PMID: 31241820)
  • 22 LAUER-FISCHER GmbH. Lauer-Taxe Online/German Drug Directory. 2020
  • 23 Bullinger M, Kirchberger I. Der SF- 36 Fragebogen zum Gesundheitszustand – Handanweisung. Göttingen: Horgrefe; 1998
  • 24 Montes ML, Olveira A, Ahumada A. et al. Similar effectiveness of direct-acting antiviral against hepatitis C virus in patients with and without HIV infection. AIDS 2017; 31: 1253-1260 DOI: 10.1097/QAD.0000000000001465. (PMID: 28358742)
  • 25 Graf C, Mücke MM, Dultz G. et al. Efficacy of Direct-acting Antivirals for Chronic Hepatitis C Virus Infection in People Who Inject Drugs or Receive Opioid Substitution Therapy: A Systematic Review and Meta-analysis. Clinical Infectious Diseases 2020; 70: 2355-2365 DOI: 10.1093/cid/ciz696. (PMID: 31513710)
  • 26 Macken L, Gelson W, Priest M. et al. Efficacy of direct-acting antivirals: UK real-world data from a well-characterised predominantly cirrhotic HCV cohort. J Med Virol 2019; 91: 1979-1988 DOI: 10.1002/jmv.25552. (PMID: 31329295)
  • 27 Zimmermann T, Jansen P, Sarrazin C. et al. S3-Leitlinie „Prophylaxe, Diagnostik und Therapie der Hepatitis-C-Virus (HCV) -Infektion“. Z Gastroenterol 2018; 56: e53-e115 DOI: 10.1055/a-0598-5242. (PMID: 29986357)
  • 28 Simon KG, Serfert Y, Buggisch P. et al. Hepatitis C-Register D: Evolution of hepatitis C virus genotype 1a vs. 1b distribution reflects profound changes of HCV epidemiology in Germany between 2004 and 2018 – Analysis of 17093 patients from five consecutive registries including the German Hepatitis C-Registry (DHC-R).
  • 29 Stahmeyer JT, Krauth C, Bert F. et al. Costs and outcomes of treating chronic hepatitis C patients in routine care – results from a nationwide multicenter trial. Journal of Viral Hepatitis 2015; 23: 105-115 DOI: 10.1111/jvh.12471. (PMID: 26411532)
  • 30 Stahmeyer JT, Rossol S, Bert F. et al. Outcomes and Costs of Treating Hepatitis C Patients in the Era of First Generation Protease Inhibitors – Results from the PAN Study. PloS one 2016; 11: e0159976 DOI: 10.1371/journal.pone.0159976. (PMID: 27467772)
  • 31 Krüger K, Krauth C, Rossol S. et al. Outcomes and costs of treating hepatitis C patients with second-generation direct-acting antivirals: results from the German Hepatitis C-registry. European Journal of Gastroenterology & Hepatology 2018; DOI: 10.1097/MEG.0000000000001283.
  • 32 Siebert U, Ravens-Sieberer U, Greiner W. et al. Performance of different utility assessment methods in chronic hepatitis C patients. In Proceedings of the 19th Plenary Meeting of the EuroQol Group 13th-14th September 2002 Discussion Papers. In: Kind P, Macran S. . York: UK Centre for Health Economics; 2003: 175-184
  • 33 Stahmeyer JT, Rossol S, Liersch S. et al. Cost-Effectiveness of Treating Hepatitis C with Sofosbuvir/Ledipasvir in Germany. PLoS ONE 2017; 12: e0169401 DOI: 10.1371/journal.pone.0169401. (PMID: 28046099)
  • 34 Kracht PM, Lieveld FI, Amelung LM de. et al. The Impact of Hepatitis C Virus Direct-Acting Antivirals on Patient-Reported Outcomes: A Dutch Prospective Cohort Study. Infect Dis Ther 2018; 7: 373-385 DOI: 10.1007/s40121-018-0208-z. (PMID: 30076582)
  • 35 Jang ES, Kim YS, Kim K. et al. Factors Associated with Health-Related Quality of Life in Korean Patients with Chronic Hepatitis C Infection Using the SF-36 and EQ-5D. Gut and Liver 2018; 12: 440-448 DOI: 10.5009/gnl17322. (PMID: 29588435)

Zoom Image
Fig. 1 Physical component summary score over time and reference values from German norm population, stratified by cirrhosis status.
Zoom Image
Fig. 2 Physical component summary score over time and reference values from German norm population, stratified by sub-population.
Zoom Image
Fig. 3 Mental component summary score over time and reference values from German norm population, stratified by cirrhosis status.
Zoom Image
Fig. 4 Mental component summary score over time and reference values from German norm population, stratified by sub-population.