Abstract
Introduction Condyloma acuminata (CA) is a sexually transmitted
infection caused by the human papillomavirus (HPV), and the recurrence rate is relatively
high. A compromised immune system causes CA recurrence. The primary treatment goal is to
eradicate the warts; however, the immunomodulatory combination therapy might reduce the
recurrence rate, so it might enhance the healing process. Cimetidine is a histamine
H2-receptor antagonist which might indicate immunomodulator activity.
Aim This case report aimed to investigate the effectiveness of
cimetidine as an immunomodulator agent against CA.
Clinical cases Three patients visited dermatology and venerology
outpatient clinic with multiple warts located on the external genital and perianal area. The
examination described there were confluent cauliflower-like nodules. Besides, acetowhite
examination showed positive reactions. Two patients were HIV-positve and one was negative. The
lesions showed clinical improvement in all three patients.
Conclusion Briefly, the cimetidine is effective as an
immunomodulator therapy to enhance the healing process and decrease the risk of CA
recurrences.
Keywords
cimetidine - condyloma acuminata - H2-receptor antagonist - warts
