Abstract
Since the first reports of their isolation, the meroterpenoids cochlearol A and B
have attracted interest from the synthetic community for their unique structural features.
This review describes the attempted and successful total syntheses of these natural
products and provides a summary of the strategies developed in the years since their
isolation.
1 Introduction
2 Overview of Cochlearol A Syntheses
3 Tong’s Approach Towards Cochlearol A
4 Liu and Qin’s Total Synthesis of (±)-Cochlearol A
5 Ishigami’s Formal Synthesis of (±)-Cochlearol A
6 Chandrasekhar’s Formal Synthesis of (±)-Cochlearol A
7 Sugita’s Synthesis of (±)-Cochlearol B
8 Schindler’s Synthesis of (+)-Cochlearol B
9 Conclusions
Key words
total synthesis -
Ganoderma cochlear
- meroterpenoid - cochlearol
