Synergetic Effect of Lupeol and Naringin Against Bile Duct Ligation
                    Induced Cardiac Injury in Rats via Modulating Nitrite Level (eNos) and NF-kB
                    /p65 Expression

Firoj Alam; Anil Kumar Kharya; Ritesh Kumar Srivastav; Juber Akhtar; Mohammad Irfan Khan; Mohammad Ahmad

doi:10.1055/a-1879-2944

Drug Research, Inhaltsverzeichnis

Drug Res (Stuttg) 2023; 73(01): 23-29
DOI: 10.1055/a-1879-2944

Original Article

Synergetic Effect of Lupeol and Naringin Against Bile Duct Ligation Induced Cardiac Injury in Rats via Modulating Nitrite Level (eNos) and NF-kB /p65 Expression

Badruddeen

Firoj Alam

¹Kunwar Haribansh Singh College of Pharmacy, Jaunpur, (U.P.), India

,

Anil Kumar Kharya

¹Kunwar Haribansh Singh College of Pharmacy, Jaunpur, (U.P.), India

,

Ritesh Kumar Srivastav

³Kamla Nehru Institute of Management & Technology, Sultanpur (U.P.), India

,

Juber Akhtar

²Faculty of Pharmacy Integral University, Lucknow (U.P.), India

,

Mohammad Irfan Khan

²Faculty of Pharmacy Integral University, Lucknow (U.P.), India

,

Mohammad Ahmad

²Faculty of Pharmacy Integral University, Lucknow (U.P.), India

› Institutsangaben

Abstract

Cardiac dysfunction such as cirrhotic cardiomyopathy is more common in liver cirrhosis related disorders including primary biliary cholangitis or biliary cirrhosis and primary sclerosing cholangitis. Bile duct ligation (BDL) is an effective model of biliary cholestasis, producing oxidative damage and fibrosis. This research was designed to evaluate the effect of Lupeol and Naringin and its combination on bile duct ligation induced cardiac injury in rats. For pharmacological evaluation, rats were randomly divided into seven groups; intrahepatic cholestasis induced by ligation of the bile duct might lead to cirrhotic cardiomyopathy. The results were analyzed by physical, biochemical and histological examination. The Lupeol (100 mg/kg, p.o.), Naringin (100 mg/kg, p.o.) and its combination (100 mg/kg each) treated group significantly improved physical infarct size, biochemical (Nitrite, SOD, CAT, and GSH) and histological (heart tissue- mitochondrial function/integrity and fibrosis) alterations occurs due to BDL-ligation. This study was concluded that oral administration of Lupeol, Naringin, and its combination has a curative potential against BDL-induced cardiac injury in rats by reducing oxidative stress and inflammatory reactions, resulting in reduced heart necrosis/myocardial infarction and increased myocardial activity. It also inhibits cardiac damage in the rat heart, these effects may be linked to the NO level (eNOS) is increased and the inactivation of the NF-kB-p65 expression pathways.This study also provides new insights into the development of lupeol and Naringin combination that can be used as supportive therapy for cardiovascular diseases.

Keywords

Bile duct ligation - Lupeol - Naringin - cardiomyopathy - NF-kB-p65 expression.

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Referenzen

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