Ir-Catalyzed α-Alkylation of Ketones with Alcohols: One-Step Access to Donepezil

Sen Wang; Rui Miao; Yanping Xia; Yifei Wei; Renshi Luo; Lu Ouyang

doi:10.1055/a-1894-8826

Synthesis, Table of Contents

Synthesis 2022; 54(23): 5253-5260
DOI: 10.1055/a-1894-8826

paper

Ir-Catalyzed α-Alkylation of Ketones with Alcohols: One-Step Access to Donepezil

Sen Wang‡

,

Rui Miao‡

,

Yanping Xia

,

Yifei Wei

,

Renshi Luo

,

Lu Ouyang∗

Abstract

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Abstract

We demonstrate an iridium-catalyzed alkylation of ketones with alcohols, which enables one-step access to donepezil, cyclic ketones, and linear ketones in high yields. A scale-up experiment shows the excellent practicability of this protocol. Comparative experiments show that a small amount of water is beneficial to the improvement of product yield.

Key words

iridium-catalyzed - borrowing hydrogen - α-alkylation - Donepezil

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References

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