Steroidal Saponins from the Rhizomes of Smilax china and Their Inhibitory Effects on Lipopolysaccharide-Induced Proinflammatory Cytokines Expression

Yu-Ting Li; Xiao Feng; Yunjiang Feng; Yuanyuan Cheng; Li-Wen Tian

doi:10.1055/a-1896-1098

Planta Medica, Inhaltsverzeichnis

Planta Med 2023; 89(02): 208-217
DOI: 10.1055/a-1896-1098

Natural Product Chemistry & Analytical Studies

Original Papers

Steroidal Saponins from the Rhizomes of Smilax china and Their Inhibitory Effects on Lipopolysaccharide-Induced Proinflammatory Cytokines Expression

Yu-Ting Li

¹Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China

,

Xiao Feng

¹Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China

,

Yunjiang Feng

²Griffith Institute for Drug Discovery, Griffith University, Brisbane, Australia

,

Yuanyuan Cheng

³School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China

,

Li-Wen Tian

¹Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China

› Institutsangaben

Abstract

Four new furostanol saponins (1 – 4) and a new pregane-type saponin (5) along with six known steroidal saponins (6 – 11) were isolated from the rhizomes of Smilax china. The structures of 1 – 5 were elucidated by extensive analysis of NMR and HR-ESI-MS data in addition to enzymatic hydrolysis and other chemical methods. Compounds 1, 4, and 11 showed inhibitory activity against the expression of proinflammatory mediators, inducible nitric oxide synthase, interleukin-1β, interleukin-6, and tumor necrosis factor-α in lipopolysaccharide-induced RAW264.7 cells. Compound 1, at a concentration of 20 µM, decreased the production of inducible nitric oxide synthase, interleukin-1β, interleukin-6, and tumor necrosis factor-α by 36, 62, 72, and 67%, respectively, which is comparable to that of the positive control dexamethasone.

Key words

Smilax china - Smilacaceae - steroidal saponins - anti-inflammatory activity

Volltext

Referenzen

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