Selective Serotonin Reuptake Inhibitors may Influence COVID-19 Prognosis through Antioxidant and Cytoprotective Pathways Mediated by Sigma 1 Receptor Agonism

• References

• 1 Min KH, Kim TH, Oh SJ. et al. COVID-19 Prognosis in Association with Antidepressant Use. Pharmacopsychiatry 2022;
• 2 Papadopoulos KI, Sutheesophon W, Aw T-C. Anti-SARS-CoV-2 Action of Fluvoxamine may be Mediated by Endothelial Nitric Oxide Synthase. Pharmacopsychiatry 2022; 55: 57-57
• 3 Albayrak Y, Hashimoto K. Sigma-1 Receptor Agonists and Their Clinical Implications in Neuropsychiatric Disorders. Adv Exp Med Biol 2017; 964: 153-161
• 4 Su TP, Su TC, Nakamura Y. et al. The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems. Trends Pharmacol Sci 2016; 37: 262-278
• 5 Sepúlveda-Fragoso V, Alexandre-Santos B, Salles ACP. et al. Crosstalk between the renin-angiotensin system and the endoplasmic reticulum stress in the cardiovascular system: Lessons learned so far. Life Sci 2021; 284: 119919
• 6 Hashimoto Y, Suzuki T, Hashimoto K. Mechanisms of action of fluvoxamine for COVID-19: a historical review. Mol Psychiatry 2022; 27: 1898-1907
• 7 Sun Y, Wan W, Zhao X. et al. Chronic Sigma 1 receptor activation alleviates right ventricular dysfunction secondary to pulmonary arterial hypertension. Bioengineered 2022; 13: 10843-10856
• 8 Olagnier D, Farahani E, Thyrsted J. et al. SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. Nat Commun 2020; 11: 4938
• 9 Jiang T, Zhao D, Zheng Z. et al. Sigma-1 Receptor Alleviates Airway Inflammation and Airway Remodeling Through AMPK/CXCR4 Signal Pathway. Inflammation 2022; 45: 1298-1312
• 10 Papadopoulos KI, Sutheesophon W, Aw TC. Too hard to die: Exercise training mediates specific and immediate SARS-CoV-2 protection. World J Virol 2022; 11: 98-103