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Synlett 2022; 33(19): 1913-1916
DOI: 10.1055/a-1921-0928
DOI: 10.1055/a-1921-0928
letter
α-Metalated Isocyanides Toward a Tangible Reagent Space
The research project (to C.G.N) was supported by the Hellenic Foundation for Research and Innovation (H.F.R.I.) under the "2nd Call for H.F.R.I. Research Projects to support Post-Doctoral Researchers” (Project Number: 0911) and by the University of Crete (UoC, ELKE).
Dedicated to Ulrich Schöllkopf, the pioneer of a-metalated isocyanide chemistry
Abstract
α-Metalated isocyanides are a versatile class of compounds that can easily be employed in various transformations, affording tangible libraries for screening campaigns. We report the ring-opening reactions of cyclic anhydrides and lactones with three different metalated isocyanides that readily give 4,5-disubstituted oxazoles, including useful drug-like synthetic intermediates with two functional groups as handles for further modifications.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1921-0928.
- Supporting Information
Publication History
Received: 20 June 2022
Accepted after revision: 08 August 2022
Accepted Manuscript online:
08 August 2022
Article published online:
09 September 2022
© 2022. Thieme. All rights reserved
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