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Synlett 2022; 33(20): 1968-1990
DOI: 10.1055/a-1925-0108
DOI: 10.1055/a-1925-0108
account
Troponoid Compounds as Therapeutic Agents and as Targets and Templates for Chemical Synthesis
We thank the National Natural Science Foundation of China (Grant No. 22250410259) and the Ministry of Science and Technology of the People’s Republic of China for financial support.
Abstract
The renewed interest in troponoid compounds as potential therapeutic agents and the ongoing discovery of new, naturally occurring and biologically active members of the class has resulted in an attendant focus on developing and deploying methods for their synthesis. This account highlights some of the significant recent developments in the area of troponoid chemistry that serve to contextualize our group’s longstanding and ongoing interest in the synthesis of such compounds through the cyclopropane-mediated ring-expansion of cyclohexanoid and benzenoid compounds. The various means by which such conversions can be accomplished and their application to the synthesis of both natural and non-natural troponoids are detailed.
1 Introduction
2 Naturally Occurring Troponoid Compounds and Their Biogenesis
3 Medicinal Chemistry Aspects of Troponoid Compounds
4 Troponoids in Materials Science
5 Troponoids as Scaffolds in Chemical Synthesis
6 An Overview of the Methods Available for Preparing Troponoids
7 Cyclopropane-Mediated Ring-Expansion Reactions Leading to Troponoids
8 Conclusions
Publication History
Received: 11 July 2022
Accepted after revision: 16 August 2022
Accepted Manuscript online:
16 August 2022
Article published online:
16 November 2022
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For useful historical introductions and key papers concerned with the pivotal early stages of the development of the chemistry of troponoids, see:
For useful reviews, see:
See, for example:
See, for example:
For related processes, see:
For useful points of entry into the substantial body of literature concerned with developing total syntheses of colchicine, see: