Trifluoromethylated Amidrazone Derivatives as Key Compounds for the Synthesis of 4-Aryl-3,5-bis(trifluoromethyl)-4H-1,2,4-triazoles

Abstract

A novel, efficient, and solvent-free approach for the synthesis of aryl-3,5-bis(trifluoromethyl)-4H-1,2,4-triazoles is disclosed via the nucleophilic intramolecular cyclization reaction of trifluoromethylated amidrazone and 2,2,2-trifluoroacetic anhydride. The trifluoromethylated amidrazone intermediates used in this project are synthesized from the reaction of N-aryl-2,2,2-trifluoroacetimidoyl chloride derivatives and hydrazine hydrate at ambient temperature in excellent yields.

Key words

aryl-3,5-bis(trifluoromethyl)-4H-1,2,4-triazole - hydrazine hydrate - trifluoromethylated amidrazones - trifluoroacetimidoyl chlorides - trifluoroacetimidohydrazides - 1,2,4-triazoles - N-heterocycles

Publication History

Received: 08 July 2022

Accepted after revision: 30 August 2022

Accepted Manuscript online:
30 August 2022

Article published online:
06 October 2022

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