Trifluoromethylated Amidrazone Derivatives as Key Compounds for the Synthesis of 4-Aryl-3,5-bis(trifluoromethyl)-4H-1,2,4-triazoles

Najmeh Zeinali; Ali Darehkordi

doi:10.1055/a-1933-3655

Synthesis, Table of Contents

Synthesis 2023; 55(04): 683-691
DOI: 10.1055/a-1933-3655

paper

Trifluoromethylated Amidrazone Derivatives as Key Compounds for the Synthesis of 4-Aryl-3,5-bis(trifluoromethyl)-4H-1,2,4-triazoles

Najmeh Zeinali

,

Ali Darehkordi

Abstract

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Abstract

A novel, efficient, and solvent-free approach for the synthesis of aryl-3,5-bis(trifluoromethyl)-4H-1,2,4-triazoles is disclosed via the nucleophilic intramolecular cyclization reaction of trifluoromethylated amidrazone and 2,2,2-trifluoroacetic anhydride. The trifluoromethylated amidrazone intermediates used in this project are synthesized from the reaction of N-aryl-2,2,2-trifluoroacetimidoyl chloride derivatives and hydrazine hydrate at ambient temperature in excellent yields.

Key words

aryl-3,5-bis(trifluoromethyl)-4H-1,2,4-triazole - hydrazine hydrate - trifluoromethylated amidrazones - trifluoroacetimidoyl chlorides - trifluoroacetimidohydrazides - 1,2,4-triazoles - N-heterocycles

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References

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