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Synthesis 2023; 55(03): 481-488
DOI: 10.1055/a-1954-4920
DOI: 10.1055/a-1954-4920
paper
Rhodium(III)-Catalyzed Intramolecular Benzylic C(sp3)–H Amidation for the Synthesis of Isoindolinones
This work was supported by the Shandong Provincial Natural Science Foundation, China (ZR2020MB006 and ZR2016JL009) and the University of Jinan.
Abstract
The synthesis of N-unprotected isoindolinones via rhodium(III)-catalyzed intramolecular C(sp3)–H amidation of various 2-methyl-N-substituted benzamides is developed. This protocol employs a free amino acid l-alanine as a ligand, which could significantly increase the reactivity of rhodium catalyst.
Key words
rhodium(III) catalyst - C(sp3)–H amidation - isoindolinones - N-substituted benzamides - synthetic methodsSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1954-4920.
- Supporting Information
Publication History
Received: 23 August 2022
Accepted after revision: 04 October 2022
Accepted Manuscript online:
04 October 2022
Article published online:
10 November 2022
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