Download PDF
Zeitschrift für Orthomolekulare Medizin 2022; 20(04): 4-10
DOI: 10.1055/a-1964-0136
Wissen

Anti-Aging und Mikronährstoffe – eine Auswahl an Anti-Seneszenz-Nutrienten

Hans-Peter Friedrichsen
,
Jörg Bergemann
,
Uwe Gröber
› Further Information
    Permissions and Reprints

Zusammenfassung

Die Bevölkerung in Deutschland ist mit einigen Mikronährstoffen, wie Vitamin D und E sowie einigen B-Vitaminen und Selen, nicht ausreichend versorgt. Doch gerade diese Nährstoffe sowie ω-3-Fettsäuren tragen dazu bei, im Alter Krankheiten vorzubeugen. ω-3-Fettsäuren bilden bspw. eine tragende Säule in der Anti-Aging-Medizin. Auch Ubichinol und Magnesium sind daran beteiligt, Alterungsprozesse zu verlangsamen, im Alter die Vitalität zu verbessern und der Entwicklung von Alterskrankheiten entgegenzuwirken.

Schlüsselwörter

Anti-Aging - Mikronährstoffe - seneszente Zelle - Oxi-Inflammaging - ω-3-Fettsäuren - Selen - Vitamin D - Coenzym Q10 - Magnesium


Publication History

Article published online:
06 December 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • Literatur

  • 1 Ben-Haim MS, Kanfi Y, Mitchell SJ. et al. Breaking the Ceiling of Human Maximal Life span. J Gerontol A Biol Sci Med Sci 2018; 73: 1465-1471
    CrossrefPubMedGoogle Scholar
  • 2 Thuppal SV, von Schacky C, Harris WS. Discrepancy between Knowledge and Perceptions of Dietary Omega-3 Fatty Acid Intake Compared with the Omega-3 Index. Nutrients 2017; 9 pii E930
    CrossrefPubMedGoogle Scholar
  • 3 von Schacky C. Omega-3 Fatty Acids in Pregnancy – The Case for a Target Omega-3 Index. Nutrients 2020; 12: 898
    CrossrefPubMedGoogle Scholar
  • 4 Jones GD, Droz B, Greve P. et al. Selenium deficiency risk predicted to increase under future climate change. Proc Natl Acad Sci U S A 2017; 114: 2848-2853
    CrossrefPubMedGoogle Scholar
  • 5 Schomburg L. Selenium Deficiency Due to Diet, Pregnancy, Severe Illness, or COVID-19 – A Preventable Trigger for Autoimmune Disease. Int J Mol Sci 2021; 22: 8532
    CrossrefPubMedGoogle Scholar
  • 6 Razaghi A, Poorebrahim M, Sarhan D. et al. Selenium stimulates the antitumour immunity: Insights to future research. Eur J Cancer 2021; 155: 256-267
    CrossrefPubMedGoogle Scholar
  • 7 Cashman KD, Dowling KG, Skrabakova Z. et al. Vitamin D deficiency in Europe: pandemic?. Am J Clin Nutr. 2016 ; 103 (4): 1033–1044
    PubMedGoogle Scholar
  • 8 Gröber U, Reichrath J, Holick MF. Live longer with vitamin D?. Nutrients 2015; 7: 1871-1880
    CrossrefPubMedGoogle Scholar
  • 9 Niedermaier T, Gredner T, Kuznia S. et al. Vitamin D supplementation to the older adult population in Germany has the cost-saving potential of preventing almost 30.000 cancer deaths per year. Mol Oncol 2021; 15: 1986-1994
    CrossrefPubMedGoogle Scholar
  • 10 Borsche L, Glauner B, von Mendel J. COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis. Nutrients 2021; 13: 3596
    CrossrefPubMedGoogle Scholar
  • 11 Gröber U, Holick MF. The coronavirus disease (COVID-19) – A supportive approach with selected micronutrients. Int J Vitam Nutr Res 2022; 92: 13-33
    CrossrefPubMedGoogle Scholar
  • 12 Moghaddam A, Heller RA, Sun Q. et al. Selenium Deficiency Is Associated with Mortality Risk from COVID-19. Nutrients 2020; 12: 2098
    CrossrefPubMedGoogle Scholar
  • 13 Xu M, Pirtskhavlava T, Farr JN. et al. Senolytics Improve Physical Function and Increase Lifespan in Old Age. Nat Med 2018; 24: 1246-1256
    CrossrefPubMedGoogle Scholar
  • 14 Fadiyah NN, Megawati G, Luftimas DE. et al. Potential of Omega 3 Supplementation for Coronavirus Disease 2019 (COVID-19): A Scoping Review. Int J Gen Med 2022; 15: 3915-3922
    CrossrefPubMedGoogle Scholar
  • 15 Bauer J, Biolo G, Cederholm T. et al. Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group. J Am Med Dir Assoc 2013; 14: 542-559
    CrossrefPubMedGoogle Scholar
  • 16 Pennings B, Boirie Y, Senden JMG. et al. Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men. Am J Clin Nutr 2011; 93: 997-1005
    CrossrefPubMedGoogle Scholar
  • 17 Bannenberg G, Serhan CN. Specialized pro-resolving lipid mediators in the inflammatory response: An update. Biochim Biophys Acta 2010; 1801: 1260-1273
    CrossrefPubMedGoogle Scholar
  • 18 Khanapure SP, Garvey DS, Janero DR, Letts LG. Eicosanoids in inflammation: Biosynthesis, pharmacology, and therapeutic frontiers. Curr Top Med Chem 2007; 7: 311-340
    CrossrefPubMedGoogle Scholar
  • 19 Hong S, Lu Y. Omega-3 fatty acid-derived resolvins and protectins in inflammation resolution and leukocyte functions: targeting novel lipid mediator pathways in mitigation of acute kidney injury. Front Immunol 2013; 4: 13
    CrossrefPubMedGoogle Scholar
  • 20 Novak TE, Babcock TA, Jho DH. et al. NF-kappa B inhibition by omega-3 fatty acids modulates LPS-stimulated macrophage TNF-alpha transcription. Am J Physiol Lung Cell Mol Physiol 2003; 284: L84-L89m
    CrossrefPubMedGoogle Scholar
  • 21 Martinon F, Burns K, Tschopp J. The Inflammasome: A Molecular Platform Triggering Activation of Inflammatory Caspases and Processing of pro-IL-1β. Mol Cell 2002; 10: 44
    CrossrefPubMedGoogle Scholar
  • 22 Martinon F, Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117: 561-574
    CrossrefPubMedGoogle Scholar
  • 23 Yan Y, Jiang W, Spinetti T. et al. Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity 2013; 38: 1154-1163
    CrossrefPubMedGoogle Scholar
  • 24 McDougle DR, Watson JE, Abdeen AA. et al. Anti-inflammatory ω-3 endocannabinoid epoxides. Proc Natl Acad Sci USA 2017; 114: E6034-E6043
    CrossrefPubMedGoogle Scholar
  • 25 Das A, Watson J, Carnevale L. et al. Omega-3 Endocannabinoid-Epoxides Are Novel Anti-inflammatory and Anti-Pain Lipid Metabolites (FS15-01-19). Curr Dev Nutr 2019; 3
    PubMedGoogle Scholar
  • 26 Watson JE, Kim JS, Das A. Emerging Class of Omega-3 Fatty Acid Endocannabinoids & Their Derivatives. Prostaglandins Other Lipid Mediat 2019; 143: 106337
    CrossrefPubMedGoogle Scholar
  • 27 Zora Djuric Z, Bassis CM, Melissa A, Plegue MA. et al. Increases in Colonic Bacterial Diversity after ω-3 Fatty Acid Supplementation Predict Decreased Colonic Prostaglandin E2 Concentrations in Healthy Adults. J Nutr 2019; 149: 1170-1179
    CrossrefPubMedGoogle Scholar
  • 28 Hu Y, Hu FB, Manson JE. Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants. J Am Heart Assoc 2019; 8: e013543
    Google Scholar
  • 29 Olsen RKJ, Cornelius N, Gregersen N. Redox signalling and mitochondrial stress responses; lessons from inborn errors of metabolism. J Inherit Metab Dis 2015; 38: 703-719
    CrossrefPubMedGoogle Scholar
  • 30 Meissner C, Mohamed S, von Wurmb N. et al. Das mitochondriale Genom und Alter. Z Gerontol Geriat 2001; 34: 447-451
    CrossrefPubMedGoogle Scholar
  • 31 Schniertshauer D, Gebhard D, van Beek H. et al. The activity of the DNA repair enzyme hOGG1 can be directly modulated by ubiquinol. DNA Repair (Amst) 2020; 87: 102784
    CrossrefPubMedGoogle Scholar
  • 32 Schniertshauer D, Gebhard D, Bergemenn J. Age-Dependent Loss of Mitochondrial Function in Epithelial Tissue Can Be Reversed by Coenzyme Q10. J Aging Res 2018; 2018: 6354680
    CrossrefPubMedGoogle Scholar
  • 33 Gröber U, Schniertshauer D, Friedrichsen HP, Bergemann J. Kardioprotektive und pleiotrope Effekte von Coenzym Q10. OM – Zs f Orthomol 2022; 20: 1-8
    Google Scholar
  • 34 Rosique-Esteban N, Guasch-Ferre M, Hernandez-Alonso P. et al. Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies. Nutrients 2018; 10: 168
    CrossrefPubMedGoogle Scholar
  • 35 Gröber U, Schmidt J, Kisters K. Magnesium in Prevention and Therapy. Nutrients 2015; 7: 8199-8226
    CrossrefPubMedGoogle Scholar
  • 36 Gröber U. Magnesium and Drugs. Int J Mol Sci 2019; 20 (9) 2094 DOI: 10.3390/ijms20092094.
    CrossrefPubMedGoogle Scholar
  • 37 Zhao B, Zang L, Zhao J. et al. Association of Magnesium Intake With Type 2 Diabetes and Total Stroke: An Updated Systematic Review and Meta-Analysis. BMJ Open 2020; 10: e032240
    CrossrefPubMedGoogle Scholar
  • 38 Shah NC, Shah GJ, Li Z. et al. Short-term magnesium deficiency downregulates telomerase, upregulates neutral sphingomyelinase and induces oxidative DNA damage in cardiovascular tissues: relevance to atherogenesis, cardiovascular diseases and aging. Int J Clin Exp Med 2014; 7: 497-514
    PubMedGoogle Scholar
  • 39 Rosanoff A, West C, Elin RJ. et al. Recommendation on an updated standardization of serum magnesium reference ranges. Eur J Nutr 2022; 61: 3697-3706
    CrossrefPubMedGoogle Scholar