Advances in Exploring Cyclopentadienyl (Cp) Rhodium Catalysts Featuring Diastereotopic or Enantiotopic Cp Faces for Asymmetric C–H Activation

Xiaoqiang Yan; Jun Wang

doi:10.1055/a-2005-5006

Synthesis, Table of Contents

Synthesis 2023; 55(09): 1309-1321
DOI: 10.1055/a-2005-5006

short review

Advances in Exploring Cyclopentadienyl (Cp) Rhodium Catalysts Featuring Diastereotopic or Enantiotopic Cp Faces for Asymmetric C–H Activation

Xiaoqiang Yan

^aKey Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510006, P. R. China

^bGuangdong Key Laboratory of Chiral Molecule and Drug Discovery, Sun Yat-Sen University, Guangzhou, 510006, P. R. China

,

Jun Wang∗

^aKey Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510006, P. R. China

^bGuangdong Key Laboratory of Chiral Molecule and Drug Discovery, Sun Yat-Sen University, Guangzhou, 510006, P. R. China

› Author Affiliations

Abstract

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Abstract

Chiral cyclopentadienyl rhodium (CpRh) complexes have emerged as a class of powerful catalysts for enantioselective C–H activation reactions. In terms of Cp ligand development, the mainstream is to design chiral ligands with C ₂ symmetry in order to avoid the problem of Cp face selectivity during their metalation with rhodium. In recent years, CpRh catalysts with diastereotopic or enantiotopic Cp faces were also revealed and successfully applied in asymmetric C–H activation. These advances are summarized in this short review together with perspectives for their future development.

1 Introduction

2 Cp Ligands with Diastereotopic Cp Faces

3 Cp Ligands with Enantiotopic Cp Faces

4 Conclusion and Outlook

Key words

cyclopentadienyl - rhodium - asymmetric C–H activation - planar chiral - diastereotopic Cp face - enantiotopic Cp face - prochiral Cp

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References

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