Abstract
Biomimetic dimerization is a fascinating pathway to natural product synthesis. By
using structurally inferior monomers, complex molecular architectures can be readily
established with distinct efficiency and elegance. In this Account, our investigation
on biomimetic dimerization in natural product synthesis has been summarized, which
includes our synthetic exploration of linderaspirone A, bi-linderone, parvistemin
A, (±)-diperezone, scabellone B, and spiroxins A/C/D.
1 Introduction
2 Biomimetic Dimerization in the Synthesis of Linderaspirone A and Bi-linderone
3 Biomimetic Dimerization in the Synthesis of Parvistemin A and (±)-Diperezone
4 Biomimetic Dimerization in the Synthesis of Scabellone B
5 Dimerization Investigation in the Synthesis of Spiroxins A/C/D
6 Conclusion
Key words
biomimetic synthesis - bioactivity - dimerization - natural product - biosynthetic
proposal - oxidative coupling - oxo-6π electrocyclization
