The value of radioembolisation therapy on metastatic liver tumours – a single centre experience

Ozgul Ekmekcioglu; Umut Erdem; Pelin Arican; Hikmet Ozvar; Ozgur Bostanci

doi:10.1055/a-2026-0851

Nuklearmedizin - NuclearMedicine, Table of Contents

Nuklearmedizin 2023; 62(03): 214-219
DOI: 10.1055/a-2026-0851

Original Article

The value of radioembolisation therapy on metastatic liver tumours – a single centre experience

Der Wert der Radioembolisationstherapie bei metastasierten Lebertumoren – eine Erfahrung aus einem einzigen Zentrum

Ozgul Ekmekcioglu

¹Nuclear Medicine, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkiye (Ringgold ID: RIN64159)

,

Umut Erdem

²Interventional Radiology Department, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkiye (Ringgold ID: RIN64159)

,

Pelin Arican

¹Nuclear Medicine, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkiye (Ringgold ID: RIN64159)

,

Hikmet Ozvar

³Radiation Oncology, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkiye (Ringgold ID: RIN64159)

,

Ozgur Bostanci

⁴Hepatobiliary and General Surgery, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkiye (Ringgold ID: RIN64159)

› Author Affiliations

Abstract

Objective Local treatments used in metastatic liver tumours efficiently control the disease and survival. Transarterial radioembolisation (TARE) is a safely used locoregional treatment method. We aim to investigate the impact of TARE on different kinds of metastatic liver tumours and the effect of pre-treatment clinical findings.

Material and Methods The patients with metastatic liver tumours referred to our department for radioembolisation were retrospectively evaluated. All patients were given a Y-90 glass microsphere after being selected by the appropriate clinical and imaging criteria, lung shunt fraction levels, vascular investigation, and macro aggregated albumin (MAA) scintigraphy performed in the angiography unit.

Results Thirty-four (17 women, 17 men) patients were suitable for the treatment. Patients were treated with 115.88±47.84 Gy Y-90 glass Microspheres. The mean survival rate was 14.59±12.59 months after treatment. Higher survival rates were detected in patients who had higher pre-treatment serum albumin levels. The optimum cut-off value of albumin to predict response to treatment was 4 g/dl with 88.89% sensitivity, 62.50% specificity, 72.73% PPV and 83.33% NPV. Furthermore, one unit increase in age increased mortality 1.152 times in our patient group.

Conclusion Radioembolisation is a safe and efficient method for controlling metastatic liver disease. Albumin levels significantly affect predicting response; higher albumin levels are related to higher survival rates. Furthermore, older age positively correlated with mortality rates in our patient group.

Keywords

Radioembolisation - Y-90 - metastatic liver tumour - albumin

Full Text

References

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