Synlett 2023; 34(13): 1597-1602
DOI: 10.1055/a-2029-4189
letter

Manganese-Mediated Aerobic Oxidative Denitroalkylation of β-Nitrostyrenes with Alkylboronic Acids

Zi-yuan Yu
,
Jing-jiang Hu
,
Ya-xuan Yu
,
Yan-qin Yuan
,
Sheng-rong Guo
This work was supported by the Natural Science Foundation of ­Zhejiang Province (No. LY19B020001) and the Special Foundation for Young Scientists of Lishui, Zhejiang (No. 2018RC09).


Abstract

An aerobic oxidative stereoselective denitroalkylation of β-nitrostyrenes under mild conditions by using an alkylboronic acid as the alkyl source was achieved. This protocol accepts a broad scope of β-nitrostyrenes and alkylboronic acids, leading to the formation of C(sp3)–C(sp2) bonds. Air was employed to reoxidize the resultant Mn(II) species back to Mn(III) during the catalytic cycle.

Supporting Information



Publication History

Received: 09 January 2023

Accepted after revision: 06 February 2023

Accepted Manuscript online:
06 February 2023

Article published online:
16 March 2023

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