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Kinder- und Jugendmedizin 2023; 23(02): 91-96
DOI: 10.1055/a-2029-6953
Schwerpunkt

Neues zur Diabetesepidemiologie

Bericht aus dem Sächsischen Kinder-Diabetes-RegisterNews in epidemiology of diabetesA report from the Childhood Diabetes Registry of Saxony
Ulf Manuwald
1   Medizinische Fakultät „Carl Gustav Carus” der TU Dresden, IPAS, Gesundheitswissenschaften/Public Health
,
Olaf Schoffer
2   Universitätsklinikum „Carl Gustav Carus“ der TU Dresden, Zentrum für Evidenzbasierte Gesundheitsversorgung (ZEGV)
,
Ulrike Rothe
3   GWT an der TU Dresden
,
Joachim Kugler
1   Medizinische Fakultät „Carl Gustav Carus” der TU Dresden, IPAS, Gesundheitswissenschaften/Public Health
,
Wieland Kiess
4   Universitätsklinik und Poliklinik für Kinder und Jugendliche Leipzig
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ZUSAMMENFASSUNG

Das Sächsische Kinder-Diabetes-Register wurde 1999 etabliert. Eine Auswertung der Daten bis 2019 zeigte einen kontinuierlichen Anstieg der Inzidenz und deutete darauf hin, dass die Periodenprävalenz sowie die letzten Inzidenzraten des Typ-1-Diabetes bei Kindern und Jugendlichen in Sachsen sich verringert oder ein Plateau erreicht haben könnten. Durch den in den weiteren Jahren (2020/2021) starken Anstieg der Inzidenz und Prävalenz setzte sich dieses sich damals andeutende Plateau bezüglich des Trends der Periodenprävalenz nicht fort.

Ob dies im Zusammenhang mit COVID19, eine echte Trendzunahme oder ein Zufallseffekt sein könnte, sollte in zukünftigen Studien unter Einbeziehung möglicher korrelierender Umweltfaktoren untersucht werden.

ABSTRACT

The Childhood Diabetes Registry of Saxony has been existing since 1999.

An analysis of the data up to 2019 showed a continuous increase in incidence and indicated that the period prevalence and the latest incidence rates for type 1 diabetes in children and adolescents in Saxony may have decreased or reached a plateau. Due to the sharp increase in incidence and prevalence over the subsequent years (2020/2021), this plateau regarding the trend of period prevalence, which was indicated at that time, did not continue.

Whether this could be related to COVID, a true trend intensification or a coincidental effect, should be investigated in future studies including potential correlating environmental factors.

Schlüsselwörter

Typ-1-Diabetes - pädiatrisch - Register - Epidemiologie - Inzidenz - Prävalenz

Keywords

Type 1 diabetes - pediatric - registry - epidemiology - incidence - prevalence


Publication History

Article published online:
19 April 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG,
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • Literatur

  • 1 Jasser-Nitsche H, Varga EM, Borkenstein HM. et al Type 1 diabetes in children and adolescents is not associated with a reduced prevalence of atopy and allergic diseases. Pediatric diabetes 2017; 18: 890-894
    CrossrefPubMedSearch in Google Scholar
  • 2 Rewers M, Hyoty H, Lernmark A. et al The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update. Curr Diab Rep 2018; 18: 136
    CrossrefPubMedSearch in Google Scholar
  • 3 Lukacs K, Panczel P, Hosszufalusi N. Environmental factors and epidemiology of childhood type 1 diabetes. Orv Hetil 2021; 162: 13-22
    CrossrefPubMedSearch in Google Scholar
  • 4 Forlenza GP, Rewers M. The epidemic of type 1 diabetes: what is it telling us?. Current opinion in endocrinology, diabetes, and obesity 2011; 18: 248-251
    CrossrefPubMedSearch in Google Scholar
  • 5 Peng H, Hagopian W. Environmental factors in the development of Type 1 diabetes. Rev Endocr Metab Disord 2006; 07: 149-162
    CrossrefPubMedSearch in Google Scholar
  • 6 Ferreira RC, Guo H, Coulson RM. et al A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes. Diabetes 2014; 63: 2538-2550
    CrossrefPubMedSearch in Google Scholar
  • 7 Manuwald U, Heinke P, Salzsieder E. et al Incidence trends of type 1 diabetes before and after the reunification in children up to 14 years of age in Saxony, Eastern Germany. PloS one 2017; 12: e0183665
    CrossrefPubMedSearch in Google Scholar
  • 8 Lerner A, Jeremais P, Matthias T.. The World Incidence and Prevalence of Autoimmune Diseases is Increasing International. Journal of Celiac Disease 2015; 03: 151-155
    CrossrefSearch in Google Scholar
  • 9 Lin X, Xu Y, Pan X. et al Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025. Scientific reports 2020; 10: 14790
    CrossrefPubMedSearch in Google Scholar
  • 10 Karvonen M, Viik-Kajander M, Moltchanova E. et al Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group. Diabetes care 2000; 23: 1516-1526
    CrossrefPubMedSearch in Google Scholar
  • 11 Patterson C, Guariguata L, Dahlquist G. et al Diabetes in the young – a global view and worldwide estimates of numbers of children with type 1 diabetes. Diabetes research and clinical practice 2014; 103: 161-175
    CrossrefPubMedSearch in Google Scholar
  • 12 Soltesz G, Patterson CC, Dahlquist G. et al Worldwide childhood type 1 diabetes incidence – what can we learn from epidemiology?. Pediatric diabetes 2007; 08 (Suppl. 06) 6-14
    CrossrefPubMedSearch in Google Scholar
  • 13 Patterson CC, Dahlquist GG, Gyürüs E. et al Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study. Lancet (London, England) 2009; 373: 2027-2033
    CrossrefPubMedSearch in Google Scholar
  • 14 Patterson CC, Gyurus E, Rosenbauer J. et al Trends in childhood type 1 diabetes incidence in Europe during 1989–2008: evidence of non-uniformity over time in rates of increase. Diabetologia 2012; 55: 2142-2147
    CrossrefPubMedSearch in Google Scholar
  • 15 Parviainen A, But A, Siljander H. et al Decreased Incidence of Type 1 Diabetes in Young Finnish Children. Diabetes care 2020; 43: 2953-2958
    CrossrefPubMedSearch in Google Scholar
  • 16 Rush T, McGeary M, Sicignano N. et al A plateau in new onset type 1 diabetes: Incidence of pediatric diabetes in the United States Military Health System. Pediatric diabetes 2018; 19: 917-922
    CrossrefPubMedSearch in Google Scholar
  • 17 Cinek O, Kulich M, Sumnik Z. The incidence of type 1 diabetes in young Czech children stopped rising. Pediatric diabetes 2012; 13: 559-563
    CrossrefPubMedSearch in Google Scholar
  • 18 Berhan Y, Waernbaum I, Lind T. et al Thirty years of prospective nationwide incidence of childhood type 1 diabetes: the accelerating increase by time tends to level off in Sweden. Diabetes 2011; 60: 577-581
    CrossrefPubMedSearch in Google Scholar
  • 19 Manuwald U, Kapellen TM, Kiess W. et al Neues zur Diabetesepidemiologie, Bericht aus dem Sächsischen Kinder-Diabetes-Register. Kinder- und Jugendmedizin 2020; 20: 7-10
    Thieme ConnectSearch in Google Scholar
  • 20 Bendas A, Rothe U, Kiess W. et al Trends in Incidence Rates during 1999–2008 and Prevalence in 2008 of Childhood Type 1 Diabetes Mellitus in Germany – Model-Based National Estimates. PloS one 2015; 10: e0132716
    CrossrefPubMedSearch in Google Scholar
  • 21 Manuwald U, Schoffer O, Kugler J. et al Trends in incidence and prevalence of type 1 diabetes between 1999 and 2019 based on the Childhood Diabetes Registry of Saxony, Germany. PloS one 2021; 16: e0262171
    CrossrefPubMedSearch in Google Scholar
  • 22 Green A, Gale EA, Patterson CC. Incidence of childhood-onset insulin-dependent diabetes mellitus: the EURODIAB ACE Study. Lancet (London, England) 1992; 339: 905-909
    CrossrefPubMedSearch in Google Scholar
  • 23 Boyle P, Parkin DM. Statistical methods for registries. In Cancer registration: principles and methods (IARC Scientific Publication no 95). Lyon, France: Jensen OM, Parkin DM, MacLennan R, et al. 1991: 126-158
    PubMedSearch in Google Scholar