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Synthesis 2023; 55(13): 2091-2098
DOI: 10.1055/a-2035-2873
DOI: 10.1055/a-2035-2873
paper
Special Issue Honoring Prof. Guoqiang Lin's Contributions to Organic Chemistry
Visible-Light-Promoted C(sp3)–H Bond Functionalization toward Aminothiazole Skeletons from Active Methylene Ketones and Thioureas
We gratefully acknowledge the Natural Science Foundation of Zhejiang Province (LZ22B020003) and the National Natural Science Foundation of China (22071171) for financial support of this work.
This paper is dedicated to Professor Guoqiang Lin on the occasion of his 80th birthday.
Abstract
A novel and efficient visible-light-induced method is developed for the one-pot synthesis of functionalized 2-aminothiazoles from easily accessible active methylene ketone derivatives and different thioureas at room temperature. The mild reaction conditions, green chemistry, straightforward work-up, and high yields of the products make this procedure useful for the construction of 2-aminothiazole derivatives.
Key words
photocatalysis - 2-aminothiazoles - cyclization - free-radical reaction - heterocyclic compoundsSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2035-2873.
- Supporting Information
Publication History
Received: 23 December 2022
Accepted after revision: 14 February 2023
Accepted Manuscript online:
14 February 2023
Article published online:
13 March 2023
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