Photo-Induced Selective Difluoroalkylation of Unactivated Alkenes to Access Difluoroalkylated Indoles

Abstract

The difluoroalkylation of unactivated alkenes with ethyl iododifluoroacetate via visible light-induced process has been developed. This transformation provides selective access to difluoroalkylated indole derivatives in good yields depending on the choice of base, solvent, as well as the loading of ethyl iododifluoroacetate.

Key words

alkenes - cycloaddition - indoles - radical reaction - photooxidation

Publication History

Received: 10 January 2023

Accepted after revision: 21 February 2023

Accepted Manuscript online:
21 February 2023

Article published online:
29 March 2023

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