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Synthesis 2023; 55(21): 3515-3525
DOI: 10.1055/a-2048-8030
DOI: 10.1055/a-2048-8030
special topic
C–H Bond Functionalization of Heterocycles
Palladium-Catalyzed Regioselective C-Arylation and C,N-Diarylation of N-Aryl-2,3-dihydrophthalazine-1,4-diones Using Diaryliodonium Salts
S.N. is thankful to the Council of Scientific and Industrial Research (CSIR), New Delhi for providing a Junior Research Fellowship. N.K.D. and C.K.M. are thankful to the Birla Institute of Technology and Science, Pilani, for providing Junior and Senior Research Fellowships, respectively. The authors acknowledge the Science and Engineering Research Board (SERB), New Delhi, for providing a research grant (CRG/2021/000131).
Abstract
Regioselective C-arylation and C,N-diarylation in 2-aryl-2,3-dihydrophthalazine-1,4-diones has been successfully accomplished with diaryliodonium salts under base-mediated slightly modified Pd-catalyzed conditions. These ligand-driven transformations provided a variety of diversely decorated bi(hetero)aryls in good-to-excellent yields, while N-arylated product could be obtained under similar Pd-catalyzed conditions in the absence of a ligand.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2048-8030.
- Supporting Information
Publication History
Received: 29 January 2023
Accepted after revision: 07 March 2023
Accepted Manuscript online:
07 March 2023
Article published online:
13 April 2023
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