Extravascular Binding of Coagulation Factor IX Gives Hemostasis a Boost

Thromb Haemost 2023; 123(08): 750
DOI: 10.1055/a-2068-0207

Invited T&H Insights

Jan Pilch

¹Institute of Clinical Hemostaseology and Transfusion Medicine, Saarland University and University Medical Center, Homburg, Germany

,

Lynn M. Knowles

¹Institute of Clinical Hemostaseology and Transfusion Medicine, Saarland University and University Medical Center, Homburg, Germany

References
1 Feng D, Stafford KA, Broze GJ, Stafford DW. Evidence of clinically significant extravascular stores of factor IX. J Thromb Haemost 2013; 11 (12) 2176-2178
2 Cheung WF, Hamaguchi N, Smith KJ, Stafford DW. The binding of human factor IX to endothelial cells is mediated by residues 3-11. J Biol Chem 1992; 267 (29) 20529-20531
3 Machado SK, Peil H, Kraushaar T. et al. Modulation of Extravascular binding of recombinant factor IX impacts duration of efficacy in mouse models. Thromb Haemost 2023; 123 (08) 751-762