Near-Infrared Hemicyanine Fluorophores with Optically Tunable Groups: A ‘Leap Forward’ for in Vivo Sensing and Imaging

Jing Huang; Long He; Jiaoliang Wang; Junchao Xu; Lin Yuan

doi:10.1055/a-2071-4549

Synlett, Table of Contents

Synlett 2024; 35(01): 21-28
DOI: 10.1055/a-2071-4549

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Functional Dyes

Near-Infrared Hemicyanine Fluorophores with Optically Tunable Groups: A ‘Leap Forward’ for in Vivo Sensing and Imaging

Jing Huang‡

^aState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, Hunan, P. R. of China

,

Long He‡

^aState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, Hunan, P. R. of China

,

Jiaoliang Wang∗

^bCollege of Materials and Chemical Engineering, Hunan City University, Yiyang 413000, Hunan, P. R. of China

,

Junchao Xu∗

^aState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, Hunan, P. R. of China

,

Lin Yuan∗

^aState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, Hunan, P. R. of China

› Author Affiliations

Abstract

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Abstract

Hemicyanine dyes, with a tunable optical site and high wavelength tailorability, are of significant importance in the fields of sensing and diagnosis. Following the discovery of the near-infrared (NIR) (650–900 nm) fluorescent dyes Changsha (CS) and Huda (HD) by our group, remarkable progress has been made in the development of hemicyanine-based probes for in vivo imaging and detecting. In this review, we summarize the key contributions made by our group in developing long-wavelength (650–1700 nm) hemicyanines and utilizing them to construct functional probes. Finally, potential drawbacks and future prospects of hemicyanine dyes/probes are discussed.

1 Introduction

2 Changsha (CS) Dyes

3 Huda (HD) Dyes

4 Construction of Hemicyanine Fluorophores in the NIR-II Region

5 Summary and Outlook

Key words

near-infrared - fluorophore - hemicyanine - molecular probe - fluorescence imaging

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References

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