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Horm Metab Res 2023; 55(07): 493-497
DOI: 10.1055/a-2091-1951
Original Article: Endocrine Care

Serum Uric Acid Levels and Recurrence Rate of Ischemic Stroke: A Meta-Analysis

Min Li
1   Department of Neurology, Affiliated Hospital of Chengde Medical College, Chengde, China
,
Hongmei Wang
1   Department of Neurology, Affiliated Hospital of Chengde Medical College, Chengde, China
,
Yanjun Gao
1   Department of Neurology, Affiliated Hospital of Chengde Medical College, Chengde, China
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Abstract

The role of serum uric acid as a factor in the recurrence of ischemic stroke stays unclear. Several studies have examined the relationship between serum uric acid and recurrence of acute ischemic stroke, with various results. Therefore, we carried out a meta-analysis to have a look at the relationship between serum uric acid levels and the potential danger of stroke recurrence in patients with ischemic stroke. Relevant experiments have been recognized via looking out the electronic databases and conference sessions. This present study included a case-control study of the impact of uric acid on the recurrence of ischemic stroke. After the assessment of eligibility, this meta-analysis included four articles in which 2452 patients with ischemic stroke were tested for their level of serum uric acid. The results obtained from this meta-analysis confirmed that improved uric acid concentrations were extensively and independently related to an accelerated and higher risk of recurrent stroke. The pooled OR (95% CI) was 1.80 (1.47, 2.20) (p<0.001). Overall, this meta-analysis shows a relationship between uric acid concentration and stroke recurrence rate. Furthermore, high uric acid levels could enhance the recurrence rate of ischemic stroke.

Key words

serum uric acid - recurrence rate - ischemic stroke - meta-analysis - cardiovascular disease


Publication History

Received: 06 December 2022

Accepted after revision: 02 May 2023

Article published online:
02 June 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
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