Suzuki–Miyaura Coupling of Aryl Nosylates with Diethanolamine Boronates

Abstract

Diethanolamine boronates (DABO boronates) have gained popularity as substrates for Suzuki–Miyaura couplings due to their ease of handling as crystalline, bench-stable solids. Similarly, 4-nitrobenzenesulfonate esters (nosylates), derived from the parent phenols, also possess the advantage of being highly crystalline and stable. Herein, we describe the development of suitable reaction conditions for the Suzuki–Miyaura cross-coupling of DABO boronates with aryl and heteroaryl nosylates.

Key words

cross-coupling - homogeneous catalysis - transition metals - palladium - process chemistry

Publication History

Received: 06 March 2023

Accepted after revision: 07 June 2023

Accepted Manuscript online:
07 June 2023

Article published online:
04 July 2023

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