A New One-Pot Synthesis of 3,6-Disubstituted Pyridazines Starting from β-Nitro-β,γ-Unsaturated Ketones
Muhammad E. I. Khan
a
Green Chemistry Group, School of Sciences and Technology, Chemistry Division, University of Camerino ChIP Research Center, Via Madonna delle Carceri, 62032 Camerino (MC), Italy
,
Lixia Yuan
a
Green Chemistry Group, School of Sciences and Technology, Chemistry Division, University of Camerino ChIP Research Center, Via Madonna delle Carceri, 62032 Camerino (MC), Italy
b
Institute of BioPharmaceutical Research, Liaocheng University, Liaocheng 252059, People’s Republic of China
a
Green Chemistry Group, School of Sciences and Technology, Chemistry Division, University of Camerino ChIP Research Center, Via Madonna delle Carceri, 62032 Camerino (MC), Italy
a
Green Chemistry Group, School of Sciences and Technology, Chemistry Division, University of Camerino ChIP Research Center, Via Madonna delle Carceri, 62032 Camerino (MC), Italy
› Author AffiliationsWe gratefully acknowledge financial support from the University of Camerino and MIUR (PON Ricerca e Innovazione 2014-2020; PRIN 2017, NATURECHEM project grant n.2017A5HXFC).
A new one-pot preparation of 3,6-disubstituted pyridazines starting from β-nitro-β,γ-unsaturated ketones and hydrazine monohydrate is presented. The protocol entails two sequential steps, leading to the isolation of the title targets in satisfactory overall yields tolerating a good variety of additional functionalities.
