Aspergillose bei Ziervogelpatienten – Teil 2: Diagnostik und Therapiemöglichkeiten

Obwohl die Aspergillose bei Ziervögeln inzwischen jahrelang erforscht wurde, bleiben ihre Diagnose und Therapie oft schwierig. Teil 2 dieses Beitrags gibt einen Überblick über aktuelle und zukünftige Diagnose- und Therapiemöglichkeiten.

Publication History

Article published online:
26 September 2023

• Literatur

• 1 Martel A. Aspergillosis. In: Speer BL. Hrsg. Current Therapy in Avian Medicine and Surgery. 1. Aufl.. St. Louis (MO): Elsevier; 2016: 63-73
• 2 Redig P. Aspergillosis. In: Samour J. Hrsg. Avian Medicine. 3. Aufl.. St. Louis (MO): Elsevier; 2016: 460-472
• 3 Cray C, Reavill D, Romagnano A. et al. Galactomannan assay and plasma protein electrophoresis findings in psittacine birds with aspergillosis. J Avian Med Surg 2009; 23 (02) 125-135
• 4 Dahlhausen B, Abbott R, VanOverloop P. Rapid detection of pathogenic Aspergillus species in avian samples by Real-Time-PCR assay: a preliminary report. Proc 25th Annu Conf Assoc Avian Vet; 2004; 37 - 40B
• 5 Jones MP, Orosz SE. The diagnosis of aspergillosis in birds. Semin Avian Exotic Pet 2000; 9: 52-58
• 6 Fischer D, Lierz M. Diagnostic procedures and available techniques for the diagnostis of aspergillosis in birds. J Exot Pet Med 2015; 24: 283-295
• 7 Tully TN, Harrison GJ. Pneumology. In: Ritchie BW. Hrsg. Avian Medicine: Principles and Application. Lake Worth (FL): Wingers; 1994: 556-581
• 8 Vanderheyden N. Aspergillosis in psittacine chicks. Proc Annu Conf Assoc Avian Vet; 1993: 207-212
• 9 Jenkins J. Aspergillosis. Proc Annu Conf Assoc Avian Vet 1991; 328-330
• 10 Forbes NA. Diagnosis of avian aspergillosis and treatment with itraconazole. Vet Rec 1992; 130: 519-520
• 11 Cray C, Tatum L. Applications of protein electrophoresis in avian diagnostics. J Avian Med Surg 1998; 12: 4-10
• 12 Cray C, King E, Rodriguez M. et al. Differences in protein fractions of avian plasma among three commercial electrophoresis systems. J Avian Med Surg 2011; 25: 102-110
• 13 Goetting V, Lee KA, Woods L. et al. Inflammatory marker profiles in an avian experimental model of aspergillosis. Med Mycol 2013; 51 (07) 696-703
• 14 Fischer D, Van Waeyenberghe L, Cray C. et al. Comparison of diagnostic tools for the detection of aspergillosis in blood samples of experimentally infected falcons. Avian Dis 2014; 58 (04) 587-598
• 15 Caliendo V, McKinney P, Bailey T. et al. Serum amyloid A as an indicator of health status in falcons. J Avian Med Surg 2013; 27 (02) 83-89
• 16 Le Loch G, Deville M, Risis E. et al. Evaluation of the serological test Platelia Aspergillus for the diagnosis of aspergillosis. Proc Eur Assoc Avian Vet Conf 2005; 260-266
• 17 Orosz S, Martel A. Avian mycoses. Proc Eur Assoc Avian Vet Conf 2009; 249-259
• 18 Burco JD, Ziccardi MH, Clemons KV. et al. Evaluation of plasma (1 → 3) – β-D-Glucan concentrations in birds naturally and experimentally infected with Aspergillus fumigatus. Avian Dis 2011; 56: 183-191
• 19 Cray C, Watson T, Arheart KL. Serosurvey and diagnostic application of antibody titers to Aspergillus in avian species. Avian Dis 2009; 53: 491-494
• 20 Ivey ES. Serologic and plasma protein electrophoretic findings in 7 psittacine birds with aspergillosis. J Avian Med Surg 2000; 14: 103-106
• 21 Dahlhausen B, Abbott R, VanOverloop P. Rapid detection of pathogenic Aspergillus species in avian samples by real-time PCR assay: a preliminary report. Proc 25th Annu Conf Assoc Avian Vet 2004; 37-40
• 22 Cray C, Watson T, Rodriguez M. et al. Application of galactomannan analysis and protein electrophoresis in the diagnosis of aspergillosis in avian species. J Zoo Wildlife Med 2009; 40: 64-70
• 23 Latif H. Development and application of an enzyme immunoassay for the detection of mycotoxin fumigaclavine A [Dissertation]. Giessen: Justus-Liebig Universität Giessen; 2010
• 24 Latif H, Curtui V, Ackermann Y. et al. Production and characterization of antibodies against fumigaclavine A. Mycotox Res 2009; 25: 159-164
• 25 Flammer K. Antifungal drug update. Proc Conf Assoc Avian Vet 2006; 3-6
• 26 Carpenter JW. Exotic Animal Formulary. Elsevier; 2017
• 27 Ziolkowska G, Tokarzewski S, Nowakiewicz A. Drug resistance of Aspergillus fumigatus strains isolated from flocks of domestic geese in Poland. Poultry Sci 2014; 93: 1106-1112
• 28 Beenaert LA, Pasmans F, Van Waeyenberghe L. et al. Avian Aspergillus fumigatus strains resistant to both itraconazole and voriconazole. Antimicrob Agents Cb 2009; 53: 2199-2201
• 29 Lyman CA, Walsh TJ. Systematically antifungal agents: a review of their pharmacology and therapeutic applications. Drugs 1992; 44: 9-35
• 30 Flammer K. An overview of antifungal therapy in birds. Proc Annu Conf Assoc Avian Vet 1993; 1-4
• 31 Orosz SE, Frazier DL. Antifungal agents: a review of their pharmacology and therapeutic indications. J Avian Med Surg 1995; 9: 8-18
• 32 Antonissen G, Martel A. Antifungal therapy in birds: old drugs in a new jacket. Vet Clin Exot Anim 2018; 21: 255-377
• 33 Rundfeldt C, Wyska E, Steckel H. et al. A model for treating avian aspergillosis: serum and lund tissue kinetics for Japanese quail (Coturnix japonica) following single and multiple aerosol exposures of a nanoparticulate itraconazole suspension. Med Mycol 2013; 51 (08) 800-810
• 34 Pardeike J, Weber S, Zarfl HP. et al. Itraconazol-loaded nanostructured lipid carriers (NLC) for pulmonary treatment of aspergillosis in falcons. Eur J Pharm Biopharm 2016; 108: 269-276