Development of Novel Catalytic Direct Syntheses of N-Unsubstituted Ketimines and Their Applications to One-Pot Reactions

Yuta Kondo; Hiroyuki Morimoto; Takashi Ohshima

doi:10.1055/a-2131-3448

Synlett, Table of Contents

Synlett 2024; 35(04): 379-393
DOI: 10.1055/a-2131-3448

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11th Singapore International Chemistry Conference (SICC-11)

Development of Novel Catalytic Direct Syntheses of N-Unsubstituted Ketimines and Their Applications to One-Pot Reactions

Yuta Kondo

^aGraduate School of Pharmaceutical Sciences, Kyushu University, Maidashi 3-1-1 Higashi-ku, Fukuoka, 812-8582, Japan

,

Hiroyuki Morimoto ∗

^aGraduate School of Pharmaceutical Sciences, Kyushu University, Maidashi 3-1-1 Higashi-ku, Fukuoka, 812-8582, Japan

^bDepartment of Applied Chemistry, Graduate School of Engineering, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu-shi, Fukuoka, 804-8550, Japan

,

Takashi Ohshima∗

^aGraduate School of Pharmaceutical Sciences, Kyushu University, Maidashi 3-1-1 Higashi-ku, Fukuoka, 812-8582, Japan

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Abstract

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Abstract

Herein, we summarize our recent efforts toward developing catalytic methods for the synthesis of N-unsubstituted ketimines and their applications to one-pot reactions for producing various nitrogen-containing compounds. This account provides detailed background, optimization, scope, and mechanistic information. We hope this work will stimulate future studies on the implementation of N-unsubstituted ketimines.

1 Introduction

2 Scandium-Catalyzed Synthesis of N-Unsubstituted Ketimines

3 Tetra-n-butylammonium Fluoride Catalyzed Synthesis of N-Unsubstituted Ketimines

4 Conclusion

Key words

N-unsubstituted ketimines - one-pot reactions - amino acid derivatives - scandium triflate - tetrabutylammonium fluoride

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References

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