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DOI: 10.1055/a-2144-4093
Sonographische Normwerte für das Schilddrüsenvolumen Erwachsener – woher kommen sie und wie sind sie zu bewerten?
Normal values for adult thyroid volume on ultrasound – where do they come from and how should they be evaluated?Zusammenfassung
Der obere Grenzwert für das Schilddrüsenvolumen beträgt bei Frauen 18 ml, bei Männern 25 ml. Diese Referenzgrößen werden fachgebietsübergreifend in vielen Kliniken und Praxen verwendet und gelehrt. Insofern sind sie auch Grundlage therapeutischer Entscheidungen. Doch wo kommen die Normalwerte für das Schilddrüsenvolumen her und auf Grundlage welcher Untersuchungen wurden sie etabliert? Sollten diese Obergrenzen in der klinischen Routine als universeller Maßstab angewendet werden und welche Faktoren können die physiologische Organgröße beeinflussen? Der folgende Artikel widmet sich einer kritischen Betrachtung der weitverbreiteten Referenzwerte für das Volumen der Schilddrüse in der erwachsenen Bevölkerung.
Abstract
The upper limit for the thyroid volume is 18 ml for women and 25 ml for men. These reference values are used and taught in many clinics and practices across several disciplines. The thyroid volume is a relevant factor for the treatment course. But where do the standard values for thyroid volumes come from, what kind of studies have been carried out to establish them? Should these upper limits be used as an universal standard in clinical routine, and which factors can influence the physiological organ size? The following article is dedicated to a critical review of the commonly used reference values for the thyroid volume of adults.
Publication History
Article published online:
09 October 2023
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Literatur
- 1 Assessment of iodine deficiency disorders and monitoring their elimination: a guide for programme managers. ISBN: 978–92–4-159582–7. 3rd ed. Geneva: World Health Organization; 2007
- 2 Hintze G, Windeler J, Baumert J. et al. Thyroid volume and goitre prevalence in the elderly as determined by ultrasound and their relationships to laboratory indices. Acta Endocrinol (Copenh) 1991; 124: 12-18 DOI: 10.1530/acta.0.1240012.
- 3 Sawicka N, Sowinski J. Correlation between thyroid volume and humoral thyroid autoimmunity after radioiodine therapy in Gravesʼ disease. Endokrynol Pol 2012; 63: 10-13
- 4 Kharchenko VP, Kotlyarov PM, Mogutov MS. et al. Ultrasound Diagnostics of Thyroid Diseases. Springer: 2010
- 5 Knudsen N, Perrild H, Christiansen E. et al. Thyroid structure and size and two-year follow-up of solitary cold thyroid nodules in an unselected population with borderline iodine deficiency. Eur J Endocrinol 2000; 142: 224-230 DOI: 10.1530/eje.0.1420224.
- 6 Zimmermann MB, Hess SY, Molinari L. et al. New reference values for thyroid volume by ultrasound in iodine-sufficient schoolchildren: a World Health Organization/Nutrition for Health and Development Iodine Deficiency Study Group Report. Am J Clin Nutr 2004; 79: 231-237 DOI: 10.1093/ajcn/79.2.231.
- 7 Hegedus L, Perrild H, Poulsen LR. et al. The determination of thyroid volume by ultrasound and its relationship to body weight, age, and sex in normal subjects. J Clin Endocrinol Metab 1983; 56: 260-263 DOI: 10.1210/jcem-56-2-260.
- 8 Berghout A, Wiersinga WM, Smits NJ. et al. Determinants of thyroid volume as measured by ultrasonography in healthy adults in a noniodine deficient area. Clin Endocrinol (Oxf) 1987; 26: 273-280 DOI: 10.1111/j.1365-2265.1987.tb00784.x.
- 9 Hsiao YL, Chang TC. Ultrasound evaluation of thyroid abnormalities and volume in Chinese adults without palpable thyroid glands. J Formos Med Assoc 1994; 93: 140-144
- 10 Barrere X, Valeix P, Preziosi P. et al. Determinants of thyroid volume in healthy French adults participating in the SU.VI.MAX cohort. Clin Endocrinol (Oxf) 2000; 52: 273-278 DOI: 10.1046/j.1365-2265.2000.00939.x.
- 11 Gomez JM, Maravall FJ, Gomez N. et al. Determinants of thyroid volume as measured by ultrasonography in healthy adults randomly selected. Clin Endocrinol (Oxf) 2000; 53: 629-634 DOI: 10.1111/j.1365-2265.2000.01138.x.
- 12 Ivanac G, Rozman B, Skreb F. et al. Ultrasonographic measurement of the thyroid volume. Coll Antropol 2004; 28: 287-291
- 13 Ahidjo ATA, Tukur M. Ultrasound determination of thyroid gland volume among adult Nigerians. Int J Radiol 2006; 14: 42-44
- 14 Adibi A, Haghighi M, Hosseini SR. et al. Thyroid abnormalities among first-degree relatives of children with congenital hypothyroidism: an ultrasound survey. Horm Res 2008; 70: 100-104 DOI: 10.1159/000139152.
- 15 Şeker S, Taş İ. Determination of Thyroid Volume and Its Relation with Isthmus Thickness. EUR J GEN MED 2010; 7: 125-129
- 16 Moghadam RN, Shajari A, Afkhami-Ardekani M. Influence of physiological factors on thyroid size determined by ultrasound. Acta Med Iran 2011; 49: 302-304
- 17 Yousef M, Sulieman A, Ahmed B. et al. Local reference ranges of thyroid volume in sudanese normal subjects using ultrasound. J Thyroid Res 2011; 2011: 935141 DOI: 10.4061/2011/935141.
- 18 Turcios S, Lence-Anta JJ, Santana JL. et al. Thyroid volume and its relation to anthropometric measures in a healthy cuban population. Eur Thyroid J 2015; 4: 55-61 DOI: 10.1159/000371346.
- 19 Sahin E, Elboga U, Kalender E. Regional reference values of thyroid gland volume in Turkish Adults. Srp Arh Celok Lek 2015; 143: 141-145 DOI: 10.2298/sarh1504141s.
- 20 Guo W, Tan L, Dong S. et al. New Reference Values for Thyroid Volume and a Comprehensive Assessment for Influencing Factors in Chinese Adults with Iodine Sufficiency. Eur Thyroid J 2021; 10: 447-454 DOI: 10.1159/000513494.
- 21 Ushakov AV. Distortion of the Maximum Norm of Thyroid Volume in Adults. ISBN: 978–5-93129–023–2. Moscow: 2017
- 22 Rasmussen LB, Ovesen L, Bulow I. et al. Relations between various measures of iodine intake and thyroid volume, thyroid nodularity, and serum thyroglobulin. Am J Clin Nutr 2002; 76: 1069-1076 DOI: 10.1093/ajcn/76.5.1069.
- 23 Carle A, Pedersen IB, Knudsen N. et al. Thyroid volume in hypothyroidism due to autoimmune disease follows a unimodal distribution: evidence against primary thyroid atrophy and autoimmune thyroiditis being distinct diseases. J Clin Endocrinol Metab 2009; 94: 833-839 DOI: 10.1210/jc.2008-1370.
- 24 Gutekunst R, Becker W, Hehrmann R. et al. Ultrasonic diagnosis of the thyroid gland. Dtsch Med Wochenschr 1988; 113: 1109-1112 DOI: 10.1055/s-2008-1067777.
- 25 Wesche MF, Wiersinga WM. Relation between lean body mass and thyroid volume in competition rowers before and during intensive physical training. Horm Metab Res 2001; 33: 423-427 DOI: 10.1055/s-2001-16232.
- 26 Wesche MF, Wiersinga WM, Smits NJ. Lean body mass as a determinant of thyroid size. Clin Endocrinol (Oxf) 1998; 48: 701-706 DOI: 10.1046/j.1365-2265.1998.00400.x.
- 27 Vannucchi G, Covelli D, Vigo B. et al. Thyroid volume and serum calcitonin changes during pregnancy. J Endocrinol Invest 2017; 40: 727-732 DOI: 10.1007/s40618-017-0622-1.
- 28 Glinoer D. What happens to the normal thyroid during pregnancy?. Thyroid 1999; 9: 631-635 DOI: 10.1089/thy.1999.9.631.
- 29 Sahin SB, Ogullar S, Ural UM. et al. Alterations of thyroid volume and nodular size during and after pregnancy in a severe iodine-deficient area. Clin Endocrinol (Oxf) 2014; 81: 762-768 DOI: 10.1111/cen.12490.
- 30 Berghout A, Endert E, Ross A. et al. Thyroid function and thyroid size in normal pregnant women living in an iodine replete area. Clin Endocrinol (Oxf) 1994; 41: 375-379 DOI: 10.1111/j.1365-2265.1994.tb02560.x.
- 31 Kotwal A, Priya R, Qadeer I. Goiter and other iodine deficiency disorders: A systematic review of epidemiological studies to deconstruct the complex web. Arch Med Res 2007; 38: 1-14 DOI: 10.1016/j.arcmed.2006.08.006.
- 32 Kowalczyk K, Franik G, Kowalczyk D. et al. Thyroid disorders in polycystic ovary syndrome. Eur Rev Med Pharmacol Sci 2017; 21: 346-360
- 33 Sahin M, Demircioglu D, Oguz A. et al. Does insulin resistance increase thyroid volume in patients with polycystic ovary syndrome?. Arch Endocrinol Metab 2017; 61: 145-151 DOI: 10.1590/2359-3997000000225.
- 34 Xiao Y, Mao J, Mao X. et al. Metabolic syndrome and its components are associated with thyroid volume in adolescents. BMC Endocr Disord 2021; 21: 176 DOI: 10.1186/s12902-021-00833-3.
- 35 Hegedus L. Thyroid size determined by ultrasound. Influence of physiological factors and non-thyroidal disease. Dan Med Bull 1990; 37: 249-263