Dedicated to Professor Ian Paterson and Professor K. C. Nicolaou
Abstract
This account summarizes the author’s endeavors in target-oriented synthesis at Seoul National University since 2011. A collection of the most celebrated molecules in total synthesis are revisited and the author’s solutions to these historical challenges are presented. In particular, the unique perception of their molecular frameworks and unprecedented bond-forming sequences form the basis of the newly developed strategies. Together with a ‘personal touch’ on these selected stories, the author hopes that this account will offer new insights and fresh perspectives for all levels of enthusiasts of target-oriented total synthesis.
1 Introduction
2.1 Synthesis of Strychnine
2.2 Synthesis of Actinophyllic Acid
2.3 Synthesis of Dendrobine
2.4 Synthesis of Communesin
2.5 Synthesis of Morphinans
2.6 Synthesis of Reserpine
2.7 Synthesis of Quinine and Quinidine
2.8 Synthesis of Haouamine
2.9 Future Work
3 Summary and Outlook
4 Abbreviations
Key words
molecular symmetry - natural products - synthetic strategy - target-oriented synthesis - total synthesis
